Lactiplantibacillus plantarum K8-based paraprobiotics prevents obesity and obesity-induced inflammatory responses in high fat diet-fed mice
DC Field | Value | Language |
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dc.contributor.author | Lim, Jeong-Ju | - |
dc.contributor.author | Jung, A-Hyun | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.contributor.author | Choi, Hyeon-Son | - |
dc.contributor.author | Kim, Hoon | - |
dc.date.accessioned | 2022-05-09T07:41:57Z | - |
dc.date.available | 2022-05-09T07:41:57Z | - |
dc.date.created | 2022-05-09 | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 0963-9969 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/140805 | - |
dc.description.abstract | This study was conducted to investigate the effect of the paraprobiotics, lactic acid bacteria lysates (LAB-P) prepared from Lactiplantibacillus plantarum K8, on obesity and obesity-induced inflammatory responses in high-fat diet (HFD)-fed mice. LAB-P (100 mg/kg) significantly decreased the HFD-induced increase in weight by approximately 20% compared to that in the HFD control. This result was accompanied by a decrease in adipose weight/size. The white adipose tissue weight of epididymis, subcutaneous inguinal region, and mesentery were decreased by 36%, 20%, and 40%, respectively, in LAB-P (100 mg/kg)-administered mice. The size of the epididymal white adipose tissue-derived adipocytes was reduced by 41%. The LAB-P-mediated reduction in adipose tissues was associated with downregulation of adipogenic factors, such as peroxisome proliferator-activated receptor gamma (PPAR gamma) and CCAAT/enhancer-binding protein alpha (C/EBP alpha). In addition, LAB-P administration reduced total cholesterol and low-density lipoprotein levels by 23% and 42%, respectively, with a 55% reduction in lactate dehydrogenase levels. Stromal vascular fraction-derived adipose tissue macrophages were favorably regulated by LAB-P administration; the expression of CD11c, an inflammatory marker, was reduced by 30%, and that of CD206, an anti-inflammatory marker, was increased by 9-fold. These results were shown to correlated with the inhibition of proinflammatory cytokines (IL-1 beta and IL-6) and downregulation of NF-kappa B expression. Furthermore, LAB-P administration suppressed HFD-induced fatty liver by activating AMPK alpha, an energy metabolic sensor. This study indicates that LAB-P effectively prevents HFD-induced obesity and obesity-induced inflammatory responses and serves a valuable basic work for utilizing LAB-P as functional food ingredient to preventing obesity and treating obesity-associated inflammatory diseases. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.subject | PROBIOTICS | - |
dc.subject | MODELS | - |
dc.subject | TERM | - |
dc.title | Lactiplantibacillus plantarum K8-based paraprobiotics prevents obesity and obesity-induced inflammatory responses in high fat diet-fed mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.1016/j.foodres.2022.111066 | - |
dc.identifier.scopusid | 2-s2.0-85125488156 | - |
dc.identifier.wosid | 000784247100012 | - |
dc.identifier.bibliographicCitation | FOOD RESEARCH INTERNATIONAL, v.155 | - |
dc.relation.isPartOf | FOOD RESEARCH INTERNATIONAL | - |
dc.citation.title | FOOD RESEARCH INTERNATIONAL | - |
dc.citation.volume | 155 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | PROBIOTICS | - |
dc.subject.keywordPlus | MODELS | - |
dc.subject.keywordPlus | TERM | - |
dc.subject.keywordAuthor | Probiotic lysate | - |
dc.subject.keywordAuthor | Postbiotics | - |
dc.subject.keywordAuthor | Anti-adipogenesis | - |
dc.subject.keywordAuthor | Adipose tissue macrophage | - |
dc.subject.keywordAuthor | AMPK alpha | - |
dc.subject.keywordAuthor | NF-kappa B | - |
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