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Lactiplantibacillus plantarum K8-based paraprobiotics prevents obesity and obesity-induced inflammatory responses in high fat diet-fed mice

Authors
Lim, Jeong-JuJung, A-HyunSuh, Hyung JooChoi, Hyeon-SonKim, Hoon
Issue Date
5월-2022
Publisher
ELSEVIER
Keywords
Probiotic lysate; Postbiotics; Anti-adipogenesis; Adipose tissue macrophage; AMPK alpha; NF-kappa B
Citation
FOOD RESEARCH INTERNATIONAL, v.155
Indexed
SCIE
SCOPUS
Journal Title
FOOD RESEARCH INTERNATIONAL
Volume
155
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/140805
DOI
10.1016/j.foodres.2022.111066
ISSN
0963-9969
Abstract
This study was conducted to investigate the effect of the paraprobiotics, lactic acid bacteria lysates (LAB-P) prepared from Lactiplantibacillus plantarum K8, on obesity and obesity-induced inflammatory responses in high-fat diet (HFD)-fed mice. LAB-P (100 mg/kg) significantly decreased the HFD-induced increase in weight by approximately 20% compared to that in the HFD control. This result was accompanied by a decrease in adipose weight/size. The white adipose tissue weight of epididymis, subcutaneous inguinal region, and mesentery were decreased by 36%, 20%, and 40%, respectively, in LAB-P (100 mg/kg)-administered mice. The size of the epididymal white adipose tissue-derived adipocytes was reduced by 41%. The LAB-P-mediated reduction in adipose tissues was associated with downregulation of adipogenic factors, such as peroxisome proliferator-activated receptor gamma (PPAR gamma) and CCAAT/enhancer-binding protein alpha (C/EBP alpha). In addition, LAB-P administration reduced total cholesterol and low-density lipoprotein levels by 23% and 42%, respectively, with a 55% reduction in lactate dehydrogenase levels. Stromal vascular fraction-derived adipose tissue macrophages were favorably regulated by LAB-P administration; the expression of CD11c, an inflammatory marker, was reduced by 30%, and that of CD206, an anti-inflammatory marker, was increased by 9-fold. These results were shown to correlated with the inhibition of proinflammatory cytokines (IL-1 beta and IL-6) and downregulation of NF-kappa B expression. Furthermore, LAB-P administration suppressed HFD-induced fatty liver by activating AMPK alpha, an energy metabolic sensor. This study indicates that LAB-P effectively prevents HFD-induced obesity and obesity-induced inflammatory responses and serves a valuable basic work for utilizing LAB-P as functional food ingredient to preventing obesity and treating obesity-associated inflammatory diseases.
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