Citromycin Isolated from the Antarctic Marine-Derived Fungi, Sporothrix sp., Inhibits Ovarian Cancer Cell Invasion via Suppression of ERK Signaling
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, He Yun | - |
dc.contributor.author | Ahn, Ji-Hye | - |
dc.contributor.author | Kwon, Haeun | - |
dc.contributor.author | Yim, Joung Han | - |
dc.contributor.author | Lee, Dongho | - |
dc.contributor.author | Choi, Jung-Hye | - |
dc.date.accessioned | 2022-06-10T08:40:34Z | - |
dc.date.available | 2022-06-10T08:40:34Z | - |
dc.date.created | 2022-06-10 | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 1660-3397 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/141831 | - |
dc.description.abstract | Recently, microorganisms and their metabolites in the Antarctic marine environment have attracted attention as useful sources for novel therapeutics, including anticancer drugs. Here, we investigated the effects of citromycin, isolated from the Antarctic marine-derived fungus, Sporothrix sp., on human ovarian cancer cells. Citromycin inhibited the migration and invasion of human ovarian cancer SKOV3 and A2780 cells, but had no cytotoxic activity against them. Additionally, it inhibited the expression of epithelial-mesenchymal transition (EMT) markers and the activation of matrix metalloproteinase (MMP)-2 and MMP9. Moreover, extracellular signal-regulated kinase (ERK)-1/2 signaling was inhibited after citromycin treatment, and the ectopic expression of ERK negated the anti-invasive activity of citromycin. Our findings suggest that citromycin inhibits the migration and invasion of human ovarian cancer cells by downregulating the expression levels of EMT markers and MMP-2/9 via inhibition of the ERK1/2 pathway. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | E-CADHERIN | - |
dc.subject | SECONDARY METABOLITES | - |
dc.subject | EXPRESSION | - |
dc.subject | MMP-9 | - |
dc.subject | METALLOPROTEINASES | - |
dc.subject | POLYKETIDES | - |
dc.subject | METASTASIS | - |
dc.subject | ANTICANCER | - |
dc.subject | TRANSITION | - |
dc.subject | MIGRATION | - |
dc.title | Citromycin Isolated from the Antarctic Marine-Derived Fungi, Sporothrix sp., Inhibits Ovarian Cancer Cell Invasion via Suppression of ERK Signaling | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Dongho | - |
dc.identifier.doi | 10.3390/md20050275 | - |
dc.identifier.scopusid | 2-s2.0-85129494870 | - |
dc.identifier.wosid | 000803249800001 | - |
dc.identifier.bibliographicCitation | MARINE DRUGS, v.20, no.5 | - |
dc.relation.isPartOf | MARINE DRUGS | - |
dc.citation.title | MARINE DRUGS | - |
dc.citation.volume | 20 | - |
dc.citation.number | 5 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | E-CADHERIN | - |
dc.subject.keywordPlus | SECONDARY METABOLITES | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MMP-9 | - |
dc.subject.keywordPlus | METALLOPROTEINASES | - |
dc.subject.keywordPlus | POLYKETIDES | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | ANTICANCER | - |
dc.subject.keywordPlus | TRANSITION | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordAuthor | citromycin | - |
dc.subject.keywordAuthor | Sporothrix sp | - |
dc.subject.keywordAuthor | ovarian cancer | - |
dc.subject.keywordAuthor | invasion | - |
dc.subject.keywordAuthor | MMP2 and MMP9 | - |
dc.subject.keywordAuthor | ERK1 | - |
dc.subject.keywordAuthor | 2 pathway | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.