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Citromycin Isolated from the Antarctic Marine-Derived Fungi, Sporothrix sp., Inhibits Ovarian Cancer Cell Invasion via Suppression of ERK Signalingopen access

Authors
Choi, He YunAhn, Ji-HyeKwon, HaeunYim, Joung HanLee, DonghoChoi, Jung-Hye
Issue Date
5월-2022
Publisher
MDPI
Keywords
citromycin; Sporothrix sp; ovarian cancer; invasion; MMP2 and MMP9; ERK1; 2 pathway
Citation
MARINE DRUGS, v.20, no.5
Indexed
SCIE
SCOPUS
Journal Title
MARINE DRUGS
Volume
20
Number
5
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/141831
DOI
10.3390/md20050275
ISSN
1660-3397
Abstract
Recently, microorganisms and their metabolites in the Antarctic marine environment have attracted attention as useful sources for novel therapeutics, including anticancer drugs. Here, we investigated the effects of citromycin, isolated from the Antarctic marine-derived fungus, Sporothrix sp., on human ovarian cancer cells. Citromycin inhibited the migration and invasion of human ovarian cancer SKOV3 and A2780 cells, but had no cytotoxic activity against them. Additionally, it inhibited the expression of epithelial-mesenchymal transition (EMT) markers and the activation of matrix metalloproteinase (MMP)-2 and MMP9. Moreover, extracellular signal-regulated kinase (ERK)-1/2 signaling was inhibited after citromycin treatment, and the ectopic expression of ERK negated the anti-invasive activity of citromycin. Our findings suggest that citromycin inhibits the migration and invasion of human ovarian cancer cells by downregulating the expression levels of EMT markers and MMP-2/9 via inhibition of the ERK1/2 pathway.
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