Flexible patch with printable and antibacterial conductive hydrogel electrodes for accelerated wound healing
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wang, Canran | - |
dc.contributor.author | Jiang, Xing | - |
dc.contributor.author | Kim, Han-Jun | - |
dc.contributor.author | Zhang, Shiming | - |
dc.contributor.author | Zhou, Xingwu | - |
dc.contributor.author | Chen, Yi | - |
dc.contributor.author | Ling, Haonan | - |
dc.contributor.author | Xue, Yumeng | - |
dc.contributor.author | Chen, Zhaowei | - |
dc.contributor.author | Qu, Moyuan | - |
dc.contributor.author | Ren, Li | - |
dc.contributor.author | Zhu, Jixiang | - |
dc.contributor.author | Libanori, Alberto | - |
dc.contributor.author | Zhu, Yangzhi | - |
dc.contributor.author | Kang, Heemin | - |
dc.contributor.author | Ahadian, Samad | - |
dc.contributor.author | Dokmeci, Mehmet R. | - |
dc.contributor.author | Servati, Peyman | - |
dc.contributor.author | He, Ximin | - |
dc.contributor.author | Gu, Zhen | - |
dc.contributor.author | Sun, Wujin | - |
dc.contributor.author | Khademhosseini, Ali | - |
dc.date.accessioned | 2022-06-22T07:41:29Z | - |
dc.date.available | 2022-06-22T07:41:29Z | - |
dc.date.created | 2022-06-22 | - |
dc.date.issued | 2022-06 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/142237 | - |
dc.description.abstract | Electrical stimulation can facilitate wound healing with high efficiency and limited side effects. However, current electrical stimulation devices have poor conformability with wounds due to their bulky nature and the rigidity of electrodes utilized. Here, a flexible electrical patch (ePatch) made with conductive hydrogel as electrodes to improve wound management was reported. The conductive hydrogel was synthesized using silver nanowire (AgNW) and methacrylated alginate (MAA), with the former chosen as the electrode material considering its antibacterial properties, and the latter used due to its clinical suitability in wound healing. The composition of the hydrogel was optimized to enable printing on medical-grade patches for personalized wound treatment. The ePatch was shown to promote re-epithelization, enhance angiogenesis, mediate immune response, and prevent infection development in the wound microenvironment. In vitro studies indicated an elevated secretion of growth factors with enhanced cell proliferation and migration ability in response to electrical stimulation. An in vivo study in the Sprague-Dawley rat model revealed a rapid wound closure within 7 days compared to 20 days of usual healing process in rodents. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | ELECTRICAL-STIMULATION | - |
dc.subject | SILVER NANOWIRES | - |
dc.subject | SKIN | - |
dc.subject | CELLS | - |
dc.subject | THERAPY | - |
dc.subject | FABRICATION | - |
dc.subject | INFECTION | - |
dc.subject | MECHANISM | - |
dc.subject | DELIVERY | - |
dc.subject | RELEASE | - |
dc.title | Flexible patch with printable and antibacterial conductive hydrogel electrodes for accelerated wound healing | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Heemin | - |
dc.identifier.doi | 10.1016/j.biomaterials.2022.121479 | - |
dc.identifier.scopusid | 2-s2.0-85128989741 | - |
dc.identifier.wosid | 000799393200002 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.285 | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 285 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | ELECTRICAL-STIMULATION | - |
dc.subject.keywordPlus | SILVER NANOWIRES | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | FABRICATION | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordAuthor | Electrical stimulation | - |
dc.subject.keywordAuthor | Wound healing | - |
dc.subject.keywordAuthor | Conductive hydrogel | - |
dc.subject.keywordAuthor | Antibacteria | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.