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Flexible patch with printable and antibacterial conductive hydrogel electrodes for accelerated wound healingopen access

Authors
Wang, CanranJiang, XingKim, Han-JunZhang, ShimingZhou, XingwuChen, YiLing, HaonanXue, YumengChen, ZhaoweiQu, MoyuanRen, LiZhu, JixiangLibanori, AlbertoZhu, YangzhiKang, HeeminAhadian, SamadDokmeci, Mehmet R.Servati, PeymanHe, XiminGu, ZhenSun, WujinKhademhosseini, Ali
Issue Date
6월-2022
Publisher
ELSEVIER SCI LTD
Keywords
Electrical stimulation; Wound healing; Conductive hydrogel; Antibacteria
Citation
BIOMATERIALS, v.285
Indexed
SCIE
SCOPUS
Journal Title
BIOMATERIALS
Volume
285
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/142237
DOI
10.1016/j.biomaterials.2022.121479
ISSN
0142-9612
Abstract
Electrical stimulation can facilitate wound healing with high efficiency and limited side effects. However, current electrical stimulation devices have poor conformability with wounds due to their bulky nature and the rigidity of electrodes utilized. Here, a flexible electrical patch (ePatch) made with conductive hydrogel as electrodes to improve wound management was reported. The conductive hydrogel was synthesized using silver nanowire (AgNW) and methacrylated alginate (MAA), with the former chosen as the electrode material considering its antibacterial properties, and the latter used due to its clinical suitability in wound healing. The composition of the hydrogel was optimized to enable printing on medical-grade patches for personalized wound treatment. The ePatch was shown to promote re-epithelization, enhance angiogenesis, mediate immune response, and prevent infection development in the wound microenvironment. In vitro studies indicated an elevated secretion of growth factors with enhanced cell proliferation and migration ability in response to electrical stimulation. An in vivo study in the Sprague-Dawley rat model revealed a rapid wound closure within 7 days compared to 20 days of usual healing process in rodents.
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