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Steroid glycosides isolated from Paris polyphylla var. chinensis aerial parts and paris saponin II induces G1/S-phase MCF-7 cell cycle arrest

Authors
Duyen, Nguyen ThiVinh, Le BaPhong, Nguyen VietKhoi, Nguyen MinhHa, Do ThiLong, Pham QuocDung, Le VietHien, Tran ThiDat, Nguyen TienLee, Ki Yong
Issue Date
9월-2022
Publisher
ELSEVIER SCI LTD
Keywords
Breast cancer; Cytotoxic activity; Paripoloside A; Paris polyphylla var; chinensis; Steroid glycosides
Citation
CARBOHYDRATE RESEARCH, v.519
Indexed
SCIE
SCOPUS
Journal Title
CARBOHYDRATE RESEARCH
Volume
519
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/142727
DOI
10.1016/j.carres.2022.108613
ISSN
0008-6215
Abstract
In our previous research on Vietnamese medicinal plants, we found that the ethanolic extract of the aerial parts of Paris polyphylla var. chinensis exhibited cytotoxic effects in vitro in the MCF-7 human cancer cell line. Here, we used combined chromatographic separations to isolate six compounds including a new steroid glycoside, paripoloside A (3), and five known compounds, from the butanol extract of the aerial parts of P. polyphylla. We unambiguously elucidated their structures based on spectroscopic data (proton and carbon-13 nuclear magnetic resonance, heteronuclear single quantum coherence, heteronuclear multiple bond correlation, correlation spectroscopy, and high-resolution electrospray ionization mass spectroscopy data), and chemical reactions. Among the isolated compounds, paris saponin II (PSII) had the strongest cytotoxic effects against MCF-7 breast cancer cells. Interestingly, PSII significantly increased the expression of p53, p21, p27, and Bax protein levels and significantly suppressed the expression of cyclin D1 and retinoblastoma protein. These data suggest that PSII may induce G1/S phase cell cycle arrest and apoptosis pathway development in MCF-7 cells. Furthermore, the MCF-7 breast cancer cells mechanism of PSII was also investigated using molecular docking. Together, our results demonstrate that isolated compounds from P. polyphylla are promising candidates as breast cancer inhibitors.
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