Development of a fluorescent nanoprobe based on an amphiphilic single-benzene-based fluorophore for lipid droplet detection and its practical applications
DC Field | Value | Language |
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dc.contributor.author | Jung, Yuna | - |
dc.contributor.author | Jin, Ji Hye | - |
dc.contributor.author | Kim, Youngseo | - |
dc.contributor.author | Oh, Ji Hyeon | - |
dc.contributor.author | Moon, Heechang | - |
dc.contributor.author | Jeong, Huisu | - |
dc.contributor.author | Kim, Jaehoon | - |
dc.contributor.author | Park, Yoon Kyung | - |
dc.contributor.author | Oh, Yohan | - |
dc.contributor.author | Park, Sungnam | - |
dc.contributor.author | Kim, Dokyoung | - |
dc.date.accessioned | 2022-08-10T16:40:20Z | - |
dc.date.available | 2022-08-10T16:40:20Z | - |
dc.date.created | 2022-08-10 | - |
dc.date.issued | 2022-07-13 | - |
dc.identifier.issn | 1477-0520 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/142755 | - |
dc.description.abstract | Lipid droplets (LDs) are crucial biological organelles connected with metabolic pathways in biological systems and diseases. To monitor the locations and accumulation of LDs in lipid-related diseases, the development of a visualization tool for LDs has gained importance. In particular, LD visualization using fluorescent probes has gained attention. Herein, a new fluorescent nanoprobe, BMeS-Ali, is developed that can sense LDs based on an amphiphilic single benzene-based fluorophore (SBBF). BMeS-Ali consists of hydrophilic (-NH2) and hydrophobic (-C12H25) moieties and exists as a micelle nanostructure in aqueous media. BMeS-Ali has a weak fluorescence, but its emission was dramatically enhanced upon exposure to the LD components such as oleic acids (OA) by reassembling its nano-formulation. BMeS-Ali showed a selective LD staining ability and great biocompatibility in cells (cancer cells and stem cells). It also showed a practical sensing ability towards biologically derived lipids and can be applied to the visualization of human fingerprints. We found that the nanoprobe BMeS-Ali has significant potential to serve as a practical dye and sensor for lipids, especially for LD imaging in the biomedical research area and broader industrial applications. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.subject | LIVER-DISEASE | - |
dc.subject | NILE RED | - |
dc.subject | BIOLOGY | - |
dc.subject | PROBES | - |
dc.subject | AIEGEN | - |
dc.title | Development of a fluorescent nanoprobe based on an amphiphilic single-benzene-based fluorophore for lipid droplet detection and its practical applications | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Sungnam | - |
dc.identifier.doi | 10.1039/d2ob00830k | - |
dc.identifier.scopusid | 2-s2.0-85133211420 | - |
dc.identifier.wosid | 000816639700001 | - |
dc.identifier.bibliographicCitation | ORGANIC & BIOMOLECULAR CHEMISTRY, v.20, no.27, pp.5423 - 5433 | - |
dc.relation.isPartOf | ORGANIC & BIOMOLECULAR CHEMISTRY | - |
dc.citation.title | ORGANIC & BIOMOLECULAR CHEMISTRY | - |
dc.citation.volume | 20 | - |
dc.citation.number | 27 | - |
dc.citation.startPage | 5423 | - |
dc.citation.endPage | 5433 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordPlus | LIVER-DISEASE | - |
dc.subject.keywordPlus | NILE RED | - |
dc.subject.keywordPlus | BIOLOGY | - |
dc.subject.keywordPlus | PROBES | - |
dc.subject.keywordPlus | AIEGEN | - |
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