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Human Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Neural Differentiation of Neural Progenitor Cellsopen access

Authors
Park, So-YeonKim, Da-SeulKim, Hyun-MunLee, Jun-KyuHwang, Dong-YounKim, Tae-HyungYou, SeungkwonHan, Dong Keun
Issue Date
Jul-2022
Publisher
MDPI
Keywords
extracellular vesicle (EV); mesenchymal stem cell; neural progenitor cell; neurogenesis; microRNA; cytokine
Citation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.23, no.13
Indexed
SCIE
SCOPUS
Journal Title
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume
23
Number
13
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/142926
DOI
10.3390/ijms23137047
ISSN
1661-6596
1422-0067
Abstract
Mesenchymal stem cells (MSCs) have been adopted in various preclinical and clinical studies because of their multipotency and low immunogenicity. However, numerous obstacles relating to safety issues remain. Therefore, MSC-derived extracellular vesicles (EVs) have been recently employed. EVs are nano-sized endoplasmic reticulum particles generated and released in cells that have similar biological functions to their origin cells. EVs act as cargo for bioactive molecules such as proteins and genetic materials and facilitate tissue regeneration. EVs obtained from adipose-derived MSC (ADMSC) also have neuroprotective and neurogenesis effects. On the basis of the versatile effects of EVs, we aimed to enhance the neural differentiation ability of ADMSC-derived EVs by elucidating the neurogenic-differentiation process. ADMSC-derived EVs isolated from neurogenesis conditioned media (differentiated EVs, dEVs) increased neurogenic ability by altering innate microRNA expression and cytokine composition. Consequently, dEVs promoted neuronal differentiation of neural progenitor cells in vitro, suggesting that dEVs are a prospective candidate for EV-based neurological disorder regeneration therapy.
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