Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Genome-Wide Association Study of Airway Wall Thickening in a Korean Chronic Obstructive Pulmonary Disease Cohortopen access

Authors
Do, Ah RaKo, Do YeonKim, JeeyoungBak, So HyeonLee, Ki YeolYoon, DankyuShin, CholKim, SoriulKim, Woo JinWon, Sungho
Issue Date
7월-2022
Publisher
MDPI
Keywords
airway wall thickening; chronic obstructive pulmonary disease; genetic variants; genome-wide association study; single-nucleotide polymorphism
Citation
GENES, v.13, no.7
Indexed
SCIE
SCOPUS
Journal Title
GENES
Volume
13
Number
7
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/143378
DOI
10.3390/genes13071258
ISSN
2073-4425
Abstract
Airway wall thickening (AWT) plays an important pathophysiological role in airway diseases such as chronic obstructive pulmonary disease (COPD). There are only a few studies on the genetic components contributing to AWT in the Korean population. This study aimed to identify AWT-related single-nucleotide polymorphisms (SNPs) using a genome-wide association study (GWAS). We performed GWAS for AWT using the CODA and KUCOPD cohorts. Thereafter, a meta-analysis was performed. Airway wall thickness was measured using automatic segmentation software. The AWT at an internal perimeter of 10 mm (AWT-Pi10) was calculated by the square root of the theoretical airway wall area using the full-width-half-maximum method. We identified a significant SNP (rs11648772, p = 1.41 x 10(-8)) located in LINC02127, near SALL1. This gene is involved in the inhibition of epithelial-mesenchymal transition in glial cells, and it affects bronchial wall depression in COPD patients. Additionally, we identified other SNPs (rs11970854, p = 1.92 x 10(-6); rs16920168, p = 5.29 x 10(-6)) involved in airway inflammation and proliferation and found that AWT is influenced by these genetic variants. Our study helps identify the genetic cause of COPD in an Asian population and provides a potential basis for treatment.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Lee, Ki Yeol photo

Lee, Ki Yeol
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE