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Urinary 3-phenoxybenzoic acid (3-PBA) levels and changes in hematological parameters in Korean adult population: A Korean National Environmental Health Survey (KoNEHS) 2012-2014 analysis

Authors
Choi, Yun-HeeLee, Ju-YeonHuh, Da-AnMoon, Kyong Whan
Issue Date
6월-2022
Publisher
ELSEVIER GMBH
Keywords
Pyrethroid; Insecticide; 3-phenoxybenzoic acid (3-PBA); Hematological parameters; Korean National Environmental Health Survey (KoNEHS)
Citation
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, v.243
Indexed
SCIE
SCOPUS
Journal Title
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
Volume
243
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/143409
DOI
10.1016/j.ijheh.2022.113988
ISSN
1438-4639
Abstract
Pyrethroid insecticides have been broadly used as pest control in agriculture and residential spaces, exerting high effectiveness of insecticidal property and relatively low toxicity to humans. Several animal studies suggested that exposure to pyrethroids may induce hematological abnormalities, thereby altering the number of blood cells and resulting in blood disorders. However, no epidemiologic study has reported on the effect of pyrethroid insecticide exposure on hematological changes, except for occupational exposure. This study aimed to investigate the effect of urinary 3-phenoxybenzoic acid (3-PBA) concentrations on hematological parameters in a representative South Korean adult population. We analyzed data from 6296 adults enrolled in the Korean National Environmental Health Survey (2012-2014). We employed multiple linear regression analysis to evaluate the association of urinary 3-PBA levels with eight hematological profiles: white blood cells (WBCs), red blood cells (RBCs), hemoglobin, hematocrit, platelets, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC). The urinary 3-PBA levels were negatively associated with WBC, RBC, and hemoglobin levels and positively associated with MCV levels. The direction and magnitude of the association between the 3-PBA and hematological parameters varied according to sex and age. The adverse effects of 3-PBA on hematological parameters were distinctive among males aged 60 years and older. In this age group, 3-PBA levels were negatively associated with the WBC, RBC, hemoglobin, hematocrit, and MCHC levels among males. This study is the first to verify that urinary 3-PBA concentrations at the levels found in a Korean population are associated with blood parameters. This finding merits further investigation to understand the impact of 3-PBA on human blood function and public health.
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Moon, Kyong Whan
보건과학대학 (보건환경융합과학부)
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