Through-skull brain imaging in vivo at visible wavelengths via dimensionality reduction adaptive-optical microscopy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jo, Yonghyeon | - |
dc.contributor.author | Lee, Ye-Ryoung | - |
dc.contributor.author | Hong, Jin Hee | - |
dc.contributor.author | Kim, Dong-Young | - |
dc.contributor.author | Kwon, Junhwan | - |
dc.contributor.author | Choi, Myunghwan | - |
dc.contributor.author | Kim, Moonseok | - |
dc.contributor.author | Choi, Wonshik | - |
dc.date.accessioned | 2022-09-24T05:40:30Z | - |
dc.date.available | 2022-09-24T05:40:30Z | - |
dc.date.created | 2022-09-23 | - |
dc.date.issued | 2022-07-29 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/143840 | - |
dc.description.abstract | Compensation of sample-induced optical aberrations is crucial for visualizing microscopic structures deep within biological tissues. However, strong multiple scattering poses a fundamental limitation for identifying and correcting the tissue-induced aberrations. Here, we introduce a label-free deep-tissue imaging technique termed dimensionality reduction adaptive-optical microscopy (DReAM) to selectively attenuate multiple scattering. We established a theoretical framework in which dimensionality reduction of a time-gated reflection matrix can attenuate uncorrelated multiple scattering while retaining a single-scattering signal with a strong wave correlation, irrespective of sample-induced aberrations. We performed mouse brain imaging in vivo through the intact skull with the probe beam at visible wavelengths. Despite the strong scattering and aberrations, DReAM offered a 17-fold enhancement of single scattering-to-multiple scattering ratio and provided high-contrast images of neural fibers in the brain cortex with the diffraction-limited spatial resolution of 412 nanometers and a 33-fold enhanced Strehl ratio. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.subject | SCATTERING MEDIUM | - |
dc.subject | RESOLUTION | - |
dc.subject | DEEP | - |
dc.subject | MODES | - |
dc.subject | LIGHT | - |
dc.title | Through-skull brain imaging in vivo at visible wavelengths via dimensionality reduction adaptive-optical microscopy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Wonshik | - |
dc.identifier.doi | 10.1126/sciadv.abo4366 | - |
dc.identifier.scopusid | 2-s2.0-85135199989 | - |
dc.identifier.wosid | 000836554300024 | - |
dc.identifier.bibliographicCitation | SCIENCE ADVANCES, v.8, no.30 | - |
dc.relation.isPartOf | SCIENCE ADVANCES | - |
dc.citation.title | SCIENCE ADVANCES | - |
dc.citation.volume | 8 | - |
dc.citation.number | 30 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | DEEP | - |
dc.subject.keywordPlus | LIGHT | - |
dc.subject.keywordPlus | MODES | - |
dc.subject.keywordPlus | RESOLUTION | - |
dc.subject.keywordPlus | SCATTERING MEDIUM | - |
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