Laboratory information management system for COVID-19 non-clinical efficacy trial dataopen accessLaboratory information management system for COVID-19 non-clinical efficacy trial data
- Other Titles
- Laboratory information management system for COVID-19 non-clinical efficacy trial data
- Authors
- 윤수현; 노현아; 진희진; 이성영; 한소율; 김성희; 김지선; 서정선; 김정진; 박인호; 오주연; 배준용; 이지은; 우선제; 서선민; 김나원; 이연우; 장희정; 홍승민; 안세희; 류광수; 염민주; 이한별; 정버드; 윤선우; 강정아; 석상혁; 이유진; 김서연; 김영빈; 황지연; 온다인; 임수연; 김솔빈; 장지윤; 이호; 김경미; 이효정; 김홍빈; 박준원; 정대균; 송대섭; 최강석; 이호영; 최양규; 최정아; 송만기; 박만성; 서준영; 남기택; 신전수; 원성호; 윤준원; 성제경
- Issue Date
- 2022
- Publisher
- 한국실험동물학회
- Keywords
- SARS-CoV-2; COVID-19; Non-clinical; Laboratory information management system; Data
- Citation
- Laboratory Animal Research, v.38, no.2, pp.119 - 127
- Indexed
- KCI
- Journal Title
- Laboratory Animal Research
- Volume
- 38
- Number
- 2
- Start Page
- 119
- End Page
- 127
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/143909
- DOI
- 10.1186/s42826-022-00127-2
- ISSN
- 1738-6055
- Abstract
- Background: As the number of large-scale studies involving multiple organizations producing data has steadily increased, an integrated system for a common interoperable format is needed. In response to the coronavirus disease 2019 (COVID-19) pandemic, a number of global efforts are underway to develop vaccines and therapeutics. We are therefore observing an explosion in the proliferation of COVID-19 data, and interoperability is highly requested in multiple institutions participating simultaneously in COVID-19 pandemic research.
Results: In this study, a laboratory information management system (LIMS) approach has been adopted to systemically manage various COVID-19 non-clinical trial data, including mortality, clinical signs, body weight, body temperature, organ weights, viral titer (viral replication and viral RNA), and multiorgan histopathology, from multiple institutions based on a web interface. The main aim of the implemented system is to integrate, standardize, and organize data collected from laboratories in multiple institutes for COVID-19 non-clinical efficacy testings. Six animal biosafety level 3 institutions proved the feasibility of our system. Substantial benefits were shown by maximizing collaborative high-quality non-clinical research.
Conclusions: This LIMS platform can be used for future outbreaks, leading to accelerated medical product development through the systematic management of extensive data from non-clinical animal studies.
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