Diagnostic Role of Tumor Markers for Hepatocellular Carcinoma in Liver Transplantation Candidates: An Analysis Using the Korean Organ Transplantation Registry Database br
DC Field | Value | Language |
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dc.contributor.author | Kang, Woo-Hyoung | - |
dc.contributor.author | Hwang, Shin | - |
dc.contributor.author | Kim, Jong Man | - |
dc.contributor.author | Lee, Kwang-Woong | - |
dc.contributor.author | Joo, Dong Jin | - |
dc.contributor.author | You, Young Kyoung | - |
dc.contributor.author | Ryu, Je Ho | - |
dc.contributor.author | Kim, Bong -Wan | - |
dc.contributor.author | Choi, Donglak | - |
dc.contributor.author | Kim, Dong-Sik | - |
dc.contributor.author | Nah, Yang Won | - |
dc.date.accessioned | 2022-10-06T05:01:46Z | - |
dc.date.available | 2022-10-06T05:01:46Z | - |
dc.date.created | 2022-10-06 | - |
dc.date.issued | 2022-09-13 | - |
dc.identifier.issn | 1425-9524 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/144079 | - |
dc.description.abstract | Background: This study analyzed pretransplant alpha-fetoprotein (AFP) and proteins induced by vitamin K absence or an-tagonist-II (PIVKA-II) in liver transplantation (LT) candidates. Material/Methods: A total of 3273 LT recipients enrolled in the Korean Organ Transplantation Registry were divided according to hepatocellular carcinoma (HCC) status and background liver disease, and AFP and PIVKA-II were compared. Results: In all patients, the median AFP and PIVKA-II were 6.3 ng/mL and 29 mAU/mL in the viable-HCC group and 3.3 ng/mL and 35 mAU/mL, respectively, in the no-HCC group (P < 0.001 for AFP and p=0.037 for PIVKA-II). In patients with hepatitis B virus infection, they were 6.0 ng/mL and 26 mAU/mL in the HCC group and 3.2 ng/mL and 21 mAU/mL in the no-HCC group, respectively (P < 0.001 and P < 0.001). In patients with hepatitis C virus infection, they were 10.7 ng/mL and 37 mAU/mL in the HCC group and 2.6 ng/mL and 21 mAU/mL in the no-HCC group, respectively (P < 0.001 and P=0.117). In alcoholic liver disease patients, they were 5.2 ng/mL and 61 mAU/mL in the HCC group and 6.4 ng/mL and 75 mAU/mL in the no-HCC group, respectively (P < 0.001 and P=0.419). In patients with other diseases, they were 7.1 ng/mL and 32 mAU/mL in the HCC group and 3.3 ng/mL and 28 mAU/mL in the no-HCC group, respectively (P < 0.001 and P=0.822). Conclusions: The results of the present study indicate that pretransplant serum AFP and PIVKA-II were highly variably ex-pressed in LT candidates with end-stage liver diseases; therefore, their values should be cautiously interpret-ed because their role in HCC diagnosis is limited. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | INT SCIENTIFIC INFORMATION, INC | - |
dc.subject | GAMMA-CARBOXY PROTHROMBIN | - |
dc.subject | ALPHA-FETOPROTEIN | - |
dc.subject | HEPATITIS-B | - |
dc.subject | DISEASE | - |
dc.subject | CANCER | - |
dc.title | Diagnostic Role of Tumor Markers for Hepatocellular Carcinoma in Liver Transplantation Candidates: An Analysis Using the Korean Organ Transplantation Registry Database br | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Sik | - |
dc.identifier.doi | 10.12659/AOT.936937 | - |
dc.identifier.scopusid | 2-s2.0-85137683386 | - |
dc.identifier.wosid | 000858427200001 | - |
dc.identifier.bibliographicCitation | ANNALS OF TRANSPLANTATION, v.27 | - |
dc.relation.isPartOf | ANNALS OF TRANSPLANTATION | - |
dc.citation.title | ANNALS OF TRANSPLANTATION | - |
dc.citation.volume | 27 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalResearchArea | Transplantation | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.relation.journalWebOfScienceCategory | Transplantation | - |
dc.subject.keywordPlus | ALPHA-FETOPROTEIN | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | GAMMA-CARBOXY PROTHROMBIN | - |
dc.subject.keywordPlus | HEPATITIS-B | - |
dc.subject.keywordAuthor | Carcinogenesis | - |
dc.subject.keywordAuthor | Hepatocellular Carcinoma | - |
dc.subject.keywordAuthor | Liver Neoplasms | - |
dc.subject.keywordAuthor | Liver Transplantation | - |
dc.subject.keywordAuthor | Tumor Marker | - |
dc.subject.keywordAuthor | Viral Hepatitis | - |
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