Diagnostic Role of Tumor Markers for Hepatocellular Carcinoma in Liver Transplantation Candidates: An Analysis Using the Korean Organ Transplantation Registry Database br
- Authors
- Kang, Woo-Hyoung; Hwang, Shin; Kim, Jong Man; Lee, Kwang-Woong; Joo, Dong Jin; You, Young Kyoung; Ryu, Je Ho; Kim, Bong -Wan; Choi, Donglak; Kim, Dong-Sik; Nah, Yang Won
- Issue Date
- 13-9월-2022
- Publisher
- INT SCIENTIFIC INFORMATION, INC
- Keywords
- Carcinogenesis; Hepatocellular Carcinoma; Liver Neoplasms; Liver Transplantation; Tumor Marker; Viral Hepatitis
- Citation
- ANNALS OF TRANSPLANTATION, v.27
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANNALS OF TRANSPLANTATION
- Volume
- 27
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/144079
- DOI
- 10.12659/AOT.936937
- ISSN
- 1425-9524
- Abstract
- Background: This study analyzed pretransplant alpha-fetoprotein (AFP) and proteins induced by vitamin K absence or an-tagonist-II (PIVKA-II) in liver transplantation (LT) candidates. Material/Methods: A total of 3273 LT recipients enrolled in the Korean Organ Transplantation Registry were divided according to hepatocellular carcinoma (HCC) status and background liver disease, and AFP and PIVKA-II were compared. Results: In all patients, the median AFP and PIVKA-II were 6.3 ng/mL and 29 mAU/mL in the viable-HCC group and 3.3 ng/mL and 35 mAU/mL, respectively, in the no-HCC group (P < 0.001 for AFP and p=0.037 for PIVKA-II). In patients with hepatitis B virus infection, they were 6.0 ng/mL and 26 mAU/mL in the HCC group and 3.2 ng/mL and 21 mAU/mL in the no-HCC group, respectively (P < 0.001 and P < 0.001). In patients with hepatitis C virus infection, they were 10.7 ng/mL and 37 mAU/mL in the HCC group and 2.6 ng/mL and 21 mAU/mL in the no-HCC group, respectively (P < 0.001 and P=0.117). In alcoholic liver disease patients, they were 5.2 ng/mL and 61 mAU/mL in the HCC group and 6.4 ng/mL and 75 mAU/mL in the no-HCC group, respectively (P < 0.001 and P=0.419). In patients with other diseases, they were 7.1 ng/mL and 32 mAU/mL in the HCC group and 3.3 ng/mL and 28 mAU/mL in the no-HCC group, respectively (P < 0.001 and P=0.822). Conclusions: The results of the present study indicate that pretransplant serum AFP and PIVKA-II were highly variably ex-pressed in LT candidates with end-stage liver diseases; therefore, their values should be cautiously interpret-ed because their role in HCC diagnosis is limited.
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