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Biosilicated collagen/beta-tricalcium phosphate composites as a BMP-2-delivering bone-graft substitute for accelerated craniofacial bone regenerationopen access

Authors
Lee, Dong KeonKi, Mi-RanKim, Euy HyunPark, Chang-JooRyu, Jae JunJang, Hyon SeokPack, Seung PilJo, Yun KeeJun, Sang Ho
Issue Date
21-4월-2021
Publisher
SPRINGERNATURE
Keywords
Osteoinductive bone substitute; Collagen/beta-TCP composite; Biosilicification; Bone morphogenetic protein-2 (BMP-2); Biomimetic materials
Citation
BIOMATERIALS RESEARCH, v.25, no.1
Indexed
SCIE
SCOPUS
KCI
Journal Title
BIOMATERIALS RESEARCH
Volume
25
Number
1
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/144686
DOI
10.1186/s40824-021-00214-w
ISSN
1226-4601
Abstract
Background: Bioceramic beta-tricalcium phosphate (beta-TCP) is used as a bone-grafting material and a therapeutic drug carrier for treatment of bone defects in the oral and maxillofacial regions due to the osteoconductivity and biocompatibility. However, the low mechanical strength and limited osteoinductivity of beta-TCP agglomerate restrict bone regenerating performance in clinical settings. Methods: Herein, a biomimetic composite is proposed as a bone morphogenetic protein-2 (BMP-2)-delivering bone graft substitute to achieve a robust bone grafting and augmented bone regeneration. Results: The sequential processes of brown algae-inspired biosilicification and collagen coating on the surface of beta TCP enable the effective incorporation of BMP-2 into the coating layer without losing its bioactivity. The sustained delivery of BMP-2 from the biosilicated collagen and beta-TCP composites promoted in vitro osteogenic behaviors of pre-osteoblasts and remarkedly accelerated in vivo bone regeneration within a rat calvarial bone defect. Conclusions: Our multicomposite bone substitutes can be practically applied to improve bone tissue growth in bone grafting applications with further expansion to general bone tissue engineering.
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