Urban particulate matters induce EGR-1 expression in keratinocytes which correlates with the severity of psoriasis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Tae Jun | - |
dc.contributor.author | Oh, Haneul | - |
dc.contributor.author | Kim, Min-Gyu | - |
dc.contributor.author | Kim, Jaehyung | - |
dc.contributor.author | Kim, Hee Joo | - |
dc.contributor.author | Son, Sang Wook | - |
dc.date.accessioned | 2022-11-04T19:42:46Z | - |
dc.date.available | 2022-11-04T19:42:46Z | - |
dc.date.created | 2022-11-04 | - |
dc.date.issued | 2021-04 | - |
dc.identifier.issn | 1738-642X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/144688 | - |
dc.description.abstract | Background Early growth response protein (Egr)-1 is a transcription factor important for cell growth and initiation of immune responses. It is significantly up-regulated in psoriatic skin. Objective We evaluated the differential expression of Egr-1 in skin lesions of plaque psoriasis and its correlation with the severity of psoriasis. We also used in vitro methods in normal keratinocytes to analyze if urban particulate matter influences Egr-1 expression. Results Egr-1 was significantly up-regulated in the psoriatic skin, specifically in the stratum basale. Its expression was positively correlated with the severity of psoriasis (rho = 0.497, P = 0.013). It was also significantly up-regulated in keratinocytes with exposure to urban particulate matters under in vitro condition. Conclusion Up-regulated expression of Egr-1 in the epidermis suggests that it plays a role in psoriasis by accelerating epidermal cell replication, to which could be attributed by urban particulate matter. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY TOXICOGENOMICS & TOXICOPROTEOMICS-KSTT | - |
dc.title | Urban particulate matters induce EGR-1 expression in keratinocytes which correlates with the severity of psoriasis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Son, Sang Wook | - |
dc.identifier.doi | 10.1007/s13273-021-00125-w | - |
dc.identifier.scopusid | 2-s2.0-85101680970 | - |
dc.identifier.wosid | 000621066300001 | - |
dc.identifier.bibliographicCitation | MOLECULAR & CELLULAR TOXICOLOGY, v.17, no.2, pp.195 - 200 | - |
dc.relation.isPartOf | MOLECULAR & CELLULAR TOXICOLOGY | - |
dc.citation.title | MOLECULAR & CELLULAR TOXICOLOGY | - |
dc.citation.volume | 17 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 195 | - |
dc.citation.endPage | 200 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002790989 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordAuthor | Early growth response protein 1 | - |
dc.subject.keywordAuthor | Psoriasis | - |
dc.subject.keywordAuthor | Urban particulate matter | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.