Urban particulate matters induce EGR-1 expression in keratinocytes which correlates with the severity of psoriasis
- Authors
- Park, Tae Jun; Oh, Haneul; Kim, Min-Gyu; Kim, Jaehyung; Kim, Hee Joo; Son, Sang Wook
- Issue Date
- 4월-2021
- Publisher
- KOREAN SOCIETY TOXICOGENOMICS & TOXICOPROTEOMICS-KSTT
- Keywords
- Early growth response protein 1; Psoriasis; Urban particulate matter
- Citation
- MOLECULAR & CELLULAR TOXICOLOGY, v.17, no.2, pp.195 - 200
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- MOLECULAR & CELLULAR TOXICOLOGY
- Volume
- 17
- Number
- 2
- Start Page
- 195
- End Page
- 200
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/144688
- DOI
- 10.1007/s13273-021-00125-w
- ISSN
- 1738-642X
- Abstract
- Background Early growth response protein (Egr)-1 is a transcription factor important for cell growth and initiation of immune responses. It is significantly up-regulated in psoriatic skin. Objective We evaluated the differential expression of Egr-1 in skin lesions of plaque psoriasis and its correlation with the severity of psoriasis. We also used in vitro methods in normal keratinocytes to analyze if urban particulate matter influences Egr-1 expression. Results Egr-1 was significantly up-regulated in the psoriatic skin, specifically in the stratum basale. Its expression was positively correlated with the severity of psoriasis (rho = 0.497, P = 0.013). It was also significantly up-regulated in keratinocytes with exposure to urban particulate matters under in vitro condition. Conclusion Up-regulated expression of Egr-1 in the epidermis suggests that it plays a role in psoriasis by accelerating epidermal cell replication, to which could be attributed by urban particulate matter.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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