Prevention of Cholesterol Gallstone Formation by Lactobacillus acidophilus ATCC 43121 and Lactobacillus fermentum MF27 in Lithogenic Diet-Induced Mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, Ju Kyoung | - |
dc.contributor.author | Kim, You Ra | - |
dc.contributor.author | Lee, Boin | - |
dc.contributor.author | Choi, Young Min | - |
dc.contributor.author | Kim, Sae Hun | - |
dc.date.accessioned | 2022-11-05T15:41:45Z | - |
dc.date.available | 2022-11-05T15:41:45Z | - |
dc.date.created | 2022-11-04 | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 2636-0772 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/144872 | - |
dc.description.abstract | The objective of this study was to evaluate the effects of Lactobacillus acidophilus ATCC 43121 and L. fermentum MF27 on biochemical indices in the serum, cholesterol metabolism in the liver and mucin expression in the gallbladder in lithogenic diet (LD)-induced C57BL/6J mice to determine the preventive effects of lactobacilli on gallstone formation. By the end of 4 wk of the experimental period, mice fed on a LD with high-fat and high-cholesterol exhibited higher levels of total and low-density lipoprotein cholesterol in the serum compared to mice fed on control diet or LD with L. acidophilus ATCC 43121 (LD+P1; p<0.05). Cholesterol-lowering effects observed in the LD+P1 and LD with L. fermentum MF27 (LD+P2) groups were associated with reduced expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the liver compared to the LD group (p<0.05). Furthermore, expression of the gel-forming mucin, including MUC5AB and MUC5B, was suppressed in the LD+P1 and LD+P2 groups compared to the LD group (p<0.05). Therefore, steady intake of both L. acidophilus ATCC 43121 and L. fermentum MF27 may have the ability to prevent the formation of cholesterol gallstones in LD-induced C57BL/6J mice. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC FOOD SCIENCE ANIMAL RESOURCES | - |
dc.subject | EICOSAPENTAENOIC ACID | - |
dc.subject | GALLBLADDER BILE | - |
dc.subject | DISEASE | - |
dc.subject | CELLS | - |
dc.title | Prevention of Cholesterol Gallstone Formation by Lactobacillus acidophilus ATCC 43121 and Lactobacillus fermentum MF27 in Lithogenic Diet-Induced Mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sae Hun | - |
dc.identifier.doi | 10.5851/kosfa.2020.e93 | - |
dc.identifier.scopusid | 2-s2.0-85103548476 | - |
dc.identifier.wosid | 000627401200015 | - |
dc.identifier.bibliographicCitation | FOOD SCIENCE OF ANIMAL RESOURCES, v.41, no.2, pp.343 - 352 | - |
dc.relation.isPartOf | FOOD SCIENCE OF ANIMAL RESOURCES | - |
dc.citation.title | FOOD SCIENCE OF ANIMAL RESOURCES | - |
dc.citation.volume | 41 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 343 | - |
dc.citation.endPage | 352 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002686869 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | EICOSAPENTAENOIC ACID | - |
dc.subject.keywordPlus | GALLBLADDER BILE | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | cholesterol gallstone | - |
dc.subject.keywordAuthor | mucin | - |
dc.subject.keywordAuthor | Lactobacillus acidophilus | - |
dc.subject.keywordAuthor | Lactobacillus fermentum | - |
dc.subject.keywordAuthor | lithogenic diet | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.