Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Prospect of ULK1 modulators in targeting regulatory T cells

Authors
Park, YoungjunJang, Jaebong
Issue Date
Dec-2022
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
Regulatory T cells; UNC-51-like kinase 1; Autophagy; Treg-targeting therapy; ULK1 modulator
Citation
BIOORGANIC CHEMISTRY, v.129
Indexed
SCIE
SCOPUS
Journal Title
BIOORGANIC CHEMISTRY
Volume
129
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/145450
DOI
10.1016/j.bioorg.2022.106141
ISSN
0045-2068
1090-2120
Abstract
Regulatory T (Treg) cells play an instrumental role in coordinating immune homeostasis via potent inhibitory effects. Defects in Treg cells lead to autoimmunity, but an overwhelming proportion of Treg cells encourages cancer progression. Hence, targeting Treg cells has emerged as a promising approach for mitigating disease severity. Recent studies have revealed that kinases are a critical component for tuning the fate of Treg cells, but the entire network of Treg-modulating kinases is still unclear. Here, we propose that the autophagy-activating UNC-51-like kinase 1 (ULK1) is a candidate for Treg cell modulation. While accumulating evidence has high-lighted the role of autophagy-related kinases in Treg cells, the ULK1-Treg cell axis is yet to be examined. In this review, we predicted the potential role of ULK1 in Treg cell modulation. Furthermore, we summarized current ULK1 activators and inhibitors that can be investigated as Treg-targeting strategies, which might have beneficial outcomes in autoimmunity and cancer.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE