Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Mild cognitive impairment is associated with poor gait performance in patients with Parkinson's diseaseopen access

Authors
Kang, Sung HoonKim, JinheeLee, JungyeunKoh, Seong-Beom
Issue Date
4-10월-2022
Publisher
FRONTIERS MEDIA SA
Keywords
Parkinson' s disease; cognitive impairment; gait disturbance; attention; frontal executive function
Citation
FRONTIERS IN AGING NEUROSCIENCE, v.14
Indexed
SCIE
SCOPUS
Journal Title
FRONTIERS IN AGING NEUROSCIENCE
Volume
14
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/145486
DOI
10.3389/fnagi.2022.1003595
ISSN
1663-4365
Abstract
Cognitive impairment may be commonly accompanied by gait disturbance in patients with Parkinson's disease (PD). However, it is still controversial whether gait disturbance is associated with mild cognitive impairment (MCI) and which cognitive function has a more important effect on specific gait parameter. Our objective was to investigate the association of gait parameters with MCI and the correlation between performance on comprehensive neuropsychological tests and gait parameters in PD patients. We enrolled 257 patients with de novo PD (111 PD-normal cognition and 146 PD-MCI). All patients underwent comprehensive neuropsychological tests and gait evaluation using the GAITRite system. We used logistic regression analysis and partial correlation to identify the association between gait parameters and MCI and correlations between neuropsychological performance and gait parameters. Gait velocity (odds ratio [OR] = 0.98, 95% confidence interval [CI] = 0.97-0.99) and stride length (OR = 0.98; 95% CI = 0.97-0.99) were associated with MCI in patients with PD. Specifically, gait velocity, stride length, and double support ratio were only associated with attention and frontal-executive function performance in patients with PD. Our findings provide insight into the relationship between gait disturbance and MCI in patients with PD. Furthermore, the evaluation of gait disturbance is necessary for PD patients with cognitive impairment.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE