Associations between the interleukin-6 rs1800795 G/C and interleukin-6 receptor rs12083537 A/G polymorphisms and response to disease-modifying antirheumatic drugs in rheumatoid arthritis: A meta-analysis
- Authors
- Lee, Young Ho; Song, Gwan Gyu
- Issue Date
- 11월-2022
- Publisher
- ELSEVIER
- Keywords
- Rheumatoid arthritis; DMARDs; IL-6; IL-6R polymorphism; Responsiveness
- Citation
- INTERNATIONAL IMMUNOPHARMACOLOGY, v.112
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL IMMUNOPHARMACOLOGY
- Volume
- 112
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/145651
- DOI
- 10.1016/j.intimp.2022.109184
- ISSN
- 1567-5769
- Abstract
- Objective: We aimed to investigate the association between interleukin-6 (IL-6) rs1800795 G/C, IL-6 receptor (IL-6R) rs12083537 A/G, and rs4329505 T/C polymorphisms and responsiveness to disease-modifying antirheu-matic drugs (DMARDs) in patients with rheumatoid arthritis (RA).Methods: We searched Medline, Embase, and Web of Science databases. We conducted a meta-analysis of studies on the association between the IL-6 rs1800795 G/C, IL-6R rs12083537 A/G and rs4329505 T/C polymorphisms and responsiveness to DMARDs in RA patients.Results: Fourteen studies from eight published articles involving 982 patients were included in this meta-analysis. The meta-analysis showed a significant association between the IL-6 rs1800795 G allele and response to DMARDs in RA (P = 0.008). Stratification by DMARD class showed that the IL-6 rs1800795 G allele was significantly associated with responsiveness to biological DMARDs (bDMARDs) (P = 0.022), but not conventional synthetic DMARDs (P = 0.145). A significant association was also found between the IL-6 rs1800795 G/C polymorphism and response to DMARDs. The meta-analysis revealed a significant association between the IL-6R rs12083537 A allele and response to tocilizumab in RA patients (P = 0.001). A significant association was also found between the IL-6R rs12083537 AA genotype and response to tocilizumab in RA patients (P = 0.001). However, no as-sociation was found between the IL-6R rs4329505 T/C polymorphism and response to tocilizumab.onclusions: This meta-analysis revealed associations between treatment response to bDMARDs and the IL-6 rs1800795 G/C polymorphism, and between response to tocilizumab and the IL-6R rs12083537 A/G poly-morphism in RA.
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