The Association Between the PTPN22 C1858T Variant and Vasculitis: A Meta-analysis Update with Trial Sequential Analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.date.accessioned | 2022-11-17T21:40:30Z | - |
dc.date.available | 2022-11-17T21:40:30Z | - |
dc.date.created | 2022-11-17 | - |
dc.date.issued | 2022-10-01 | - |
dc.identifier.issn | 1945-0265 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/145681 | - |
dc.description.abstract | Objective: The present study was designed to determine whether the protein tyrosine phosphatase non-receptor 22 (PTPN22) C1858T variant is associated with susceptibility to vasculitis.Methods: A meta-analysis was conducted to evaluate the association between the PTPN22 C1858T variant and vasculitis. A trial sequential analysis was performed to evaluate the robustness of the meta-analysis.Results: A total of 17 studies were included in this meta-analysis which revealed a highly significant association between the PTPN22 T allele and vasculitis of multiple types (odds ratio [OR] = 4.850, 95% confidence interval [CI] = 3.043-7.729, p < 0.001). Meta-analysis by vasculitis type showed an association between the T allele and risk of giant cell arteritis (GCA) and antineutrophil cytoplasmic antibody-associated vasculitis (AAV) (OR = 7.505, 95% CI = 3.605-15.62, p < 0.001; OR = 6.121, 95% CI = 3.216-11.65, p < 0.001). The meta-analysis also indicated an association between the T allele and Takayasu's arteritis, but not between the T allele and Behcet's disease or Henoch-Schonlein purpura. TSA indicated that the observed association is conclusive with the existing evidence.Conclusions: This meta-analysis confirms that the PTPN22 C1858T variant is associated with susceptibility to GCA and AAV. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.subject | SINGLE NUCLEOTIDE POLYMORPHISM | - |
dc.subject | LYMPHOID PROTEIN PHOSPHATASE | - |
dc.subject | TYROSINE-PHOSPHATASE | - |
dc.subject | FUNCTIONAL VARIANT | - |
dc.subject | R620W POLYMORPHISM | - |
dc.subject | GENE POLYMORPHISM | - |
dc.subject | SUSCEPTIBILITY | - |
dc.title | The Association Between the PTPN22 C1858T Variant and Vasculitis: A Meta-analysis Update with Trial Sequential Analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.1089/gtmb.2022.0119 | - |
dc.identifier.scopusid | 2-s2.0-85141003723 | - |
dc.identifier.wosid | 000877290800006 | - |
dc.identifier.bibliographicCitation | GENETIC TESTING AND MOLECULAR BIOMARKERS, v.26, no.10, pp.492 - 500 | - |
dc.relation.isPartOf | GENETIC TESTING AND MOLECULAR BIOMARKERS | - |
dc.citation.title | GENETIC TESTING AND MOLECULAR BIOMARKERS | - |
dc.citation.volume | 26 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 492 | - |
dc.citation.endPage | 500 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.subject.keywordPlus | SINGLE NUCLEOTIDE POLYMORPHISM | - |
dc.subject.keywordPlus | LYMPHOID PROTEIN PHOSPHATASE | - |
dc.subject.keywordPlus | TYROSINE-PHOSPHATASE | - |
dc.subject.keywordPlus | FUNCTIONAL VARIANT | - |
dc.subject.keywordPlus | R620W POLYMORPHISM | - |
dc.subject.keywordPlus | GENE POLYMORPHISM | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordAuthor | vasculitis | - |
dc.subject.keywordAuthor | protein tyrosine phosphatase nonreceptor 22 | - |
dc.subject.keywordAuthor | variant | - |
dc.subject.keywordAuthor | meta-analysis | - |
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