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The Association Between the PTPN22 C1858T Variant and Vasculitis: A Meta-analysis Update with Trial Sequential Analysis

Authors
Lee, Young HoSong, Gwan Gyu
Issue Date
1-10월-2022
Publisher
MARY ANN LIEBERT, INC
Keywords
vasculitis; protein tyrosine phosphatase nonreceptor 22; variant; meta-analysis
Citation
GENETIC TESTING AND MOLECULAR BIOMARKERS, v.26, no.10, pp.492 - 500
Indexed
SCIE
SCOPUS
Journal Title
GENETIC TESTING AND MOLECULAR BIOMARKERS
Volume
26
Number
10
Start Page
492
End Page
500
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/145681
DOI
10.1089/gtmb.2022.0119
ISSN
1945-0265
Abstract
Objective: The present study was designed to determine whether the protein tyrosine phosphatase non-receptor 22 (PTPN22) C1858T variant is associated with susceptibility to vasculitis.Methods: A meta-analysis was conducted to evaluate the association between the PTPN22 C1858T variant and vasculitis. A trial sequential analysis was performed to evaluate the robustness of the meta-analysis.Results: A total of 17 studies were included in this meta-analysis which revealed a highly significant association between the PTPN22 T allele and vasculitis of multiple types (odds ratio [OR] = 4.850, 95% confidence interval [CI] = 3.043-7.729, p < 0.001). Meta-analysis by vasculitis type showed an association between the T allele and risk of giant cell arteritis (GCA) and antineutrophil cytoplasmic antibody-associated vasculitis (AAV) (OR = 7.505, 95% CI = 3.605-15.62, p < 0.001; OR = 6.121, 95% CI = 3.216-11.65, p < 0.001). The meta-analysis also indicated an association between the T allele and Takayasu's arteritis, but not between the T allele and Behcet's disease or Henoch-Schonlein purpura. TSA indicated that the observed association is conclusive with the existing evidence.Conclusions: This meta-analysis confirms that the PTPN22 C1858T variant is associated with susceptibility to GCA and AAV.
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