Myostatin/Appendicular Skeletal Muscle Mass (ASM) Ratio, Not Myostatin, Is Associated with Low Handgrip Strength in Community-Dwelling Older Womenopen access
- Authors
- Choi, Soo Jeong; Lee, Min Sung; Kang, Duk-Hee; Ko, Gang Jee; Lim, Hee-Sook; Yu, Byung Chul; Park, Moo Yong; Kim, Jin Kuk; Kim, Chul-Hee; Hwang, Seung Duk; Kim, Jun Chul; Won, Chang Won; An, Won Suk
- Issue Date
- 7월-2021
- Publisher
- MDPI
- Keywords
- myostatin; skeletal muscle mass; elderly
- Citation
- INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v.18, no.14
- Indexed
- SCIE
SSCI
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
- Volume
- 18
- Number
- 14
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/146105
- DOI
- 10.3390/ijerph18147344
- ISSN
- 1661-7827
- Abstract
- Background/Aims: Elevated levels of serum myostatin have been proposed as a biomarker for sarcopenia. Recent studies have shown that elevated level of serum myostatin was associated with physical fitness and performance. This study aimed to examine the significance of myostatin in the association between muscle mass and physical performance in the elderly. Methods: This cross-sectional study is based on the Korean Frailty and Aging Cohort study involving 1053 people aged 70 years or over. Anthropometric, physical performance, and laboratory data were collected. Results: The mean age of the participants was 75.8 years, and 50.7% of them were female. Serum myostatin levels in men (3.7 +/- 1.2 vs. 3.2 +/- 1.1 ng/mL, p < 0.001) were higher compared with that in women. Serum myostatin level was associated with appendicular skeletal muscle mass (ASM) index and eGFR by cystatin C. Serum myostatin/ASM ratio was associated with handgrip strength in women. Conclusion: Higher serum myostatin levels were related with higher muscle mass and better physical performances in the elderly. Serum myostatin/ASM ratio may be a predictor for physical performance rather than myostatin.
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