Association between metformin and survival outcomes in in-hospital cardiac arrest patients with diabetes
DC Field | Value | Language |
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dc.contributor.author | Jin, Bo-Yeong | - |
dc.contributor.author | Song, Juhyun | - |
dc.contributor.author | Kim, Jooyeong | - |
dc.contributor.author | Park, Jong-Hak | - |
dc.contributor.author | Kim, Sung Jin | - |
dc.contributor.author | Cho, Hanjin | - |
dc.contributor.author | Moon, Sungwoo | - |
dc.contributor.author | Kim, Dong-Hoon | - |
dc.contributor.author | Ahn, Sejoong | - |
dc.date.accessioned | 2022-12-08T06:42:25Z | - |
dc.date.available | 2022-12-08T06:42:25Z | - |
dc.date.created | 2022-12-08 | - |
dc.date.issued | 2023-02 | - |
dc.identifier.issn | 0883-9441 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/146449 | - |
dc.description.abstract | Introduction: Metformin has shown cardioprotective and neuroprotective effects in cardiac arrest and ischemia-reperfusion injury animal models. Therefore, this study aimed to determine the association between diabetes medication and survival outcomes in in-hospital cardiac arrest (IHCA) patients with type 2 DM (T2DM). Methods: This retrospective observational study included adult IHCA patients with T2DM between April 2017 and March 2022. The variable of interest was administration of diabetes medications within 24 h before cardiac arrest. Multivariable logistic regression analysis was performed.Results: In the 377 included patients, administration of metformin within 24 h before IHCA was associated with a higher rate of survival to discharge and good neurologic outcome (41.5% vs 11.7%, P < 0.001 and 18.9% vs 6.2%, P = 0.004, respectively). Administration of metformin within 24 h before IHCA was independently associated with survival to discharge and good neurologic outcome (aOR: 5.37, 95% CI: 2.13-13.53, P < 0.001 and aOR: 3.57, 95% CI: 1.14-11.17, P = 0.029). The rate of survival to discharge was the highest in patients who were administered 500-1000 mg/day metformin (P < 0.001). Conclusions: In IHCA patients with T2DM, administration of metformin within 24 h before IHCA was independently associated with survival to discharge.(c) 2022 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | W B SAUNDERS CO-ELSEVIER INC | - |
dc.title | Association between metformin and survival outcomes in in-hospital cardiac arrest patients with diabetes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Juhyun | - |
dc.contributor.affiliatedAuthor | Park, Jong-Hak | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Hoon | - |
dc.identifier.doi | 10.1016/j.jcrc.2022.154171 | - |
dc.identifier.scopusid | 2-s2.0-85140234397 | - |
dc.identifier.wosid | 000878820900002 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CRITICAL CARE, v.73 | - |
dc.relation.isPartOf | JOURNAL OF CRITICAL CARE | - |
dc.citation.title | JOURNAL OF CRITICAL CARE | - |
dc.citation.volume | 73 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Critical Care Medicine | - |
dc.subject.keywordPlus | HEART-FAILURE | - |
dc.subject.keywordPlus | MELLITUS | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | STROKE | - |
dc.subject.keywordAuthor | IHCA | - |
dc.subject.keywordAuthor | Type 2 diabetes mellitus | - |
dc.subject.keywordAuthor | Diabetic medication | - |
dc.subject.keywordAuthor | Biguanide | - |
dc.subject.keywordAuthor | Survival to discharge | - |
dc.subject.keywordAuthor | Good neurologic outcome | - |
dc.subject.keywordAuthor | Mortality | - |
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