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Association between metformin and survival outcomes in in-hospital cardiac arrest patients with diabetes

Authors
Jin, Bo-YeongSong, JuhyunKim, JooyeongPark, Jong-HakKim, Sung JinCho, HanjinMoon, SungwooKim, Dong-HoonAhn, Sejoong
Issue Date
2월-2023
Publisher
W B SAUNDERS CO-ELSEVIER INC
Keywords
IHCA; Type 2 diabetes mellitus; Diabetic medication; Biguanide; Survival to discharge; Good neurologic outcome; Mortality
Citation
JOURNAL OF CRITICAL CARE, v.73
Indexed
SCOPUS
Journal Title
JOURNAL OF CRITICAL CARE
Volume
73
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/146449
DOI
10.1016/j.jcrc.2022.154171
ISSN
0883-9441
Abstract
Introduction: Metformin has shown cardioprotective and neuroprotective effects in cardiac arrest and ischemia-reperfusion injury animal models. Therefore, this study aimed to determine the association between diabetes medication and survival outcomes in in-hospital cardiac arrest (IHCA) patients with type 2 DM (T2DM). Methods: This retrospective observational study included adult IHCA patients with T2DM between April 2017 and March 2022. The variable of interest was administration of diabetes medications within 24 h before cardiac arrest. Multivariable logistic regression analysis was performed.Results: In the 377 included patients, administration of metformin within 24 h before IHCA was associated with a higher rate of survival to discharge and good neurologic outcome (41.5% vs 11.7%, P < 0.001 and 18.9% vs 6.2%, P = 0.004, respectively). Administration of metformin within 24 h before IHCA was independently associated with survival to discharge and good neurologic outcome (aOR: 5.37, 95% CI: 2.13-13.53, P < 0.001 and aOR: 3.57, 95% CI: 1.14-11.17, P = 0.029). The rate of survival to discharge was the highest in patients who were administered 500-1000 mg/day metformin (P < 0.001). Conclusions: In IHCA patients with T2DM, administration of metformin within 24 h before IHCA was independently associated with survival to discharge.(c) 2022 Elsevier Inc. All rights reserved.
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