Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Immunostimulatory Effect of Postbiotics Prepared from Phellinus linteus Mycelial Submerged Culture via Activation of Spleen and Peyer's Patch in C3H/HeN Miceopen access

Authors
Suh, Min GeunShin, Hyun YoungJeong, Eun-JinKim, GaeulehJeong, Se BinHa, Eun JiChoi, Sang-YongMoon, Sung-KwonYu, Kwang-WonSuh, Hyung-JooKim, Hoon
Issue Date
10월-2022
Publisher
MDPI
Keywords
medicinal mushroom; submerged culture-derived postbiotics; intestinal immune system-modulating activity; spleen-mediated immunity; polysaccharide
Citation
PHARMACEUTICALS, v.15, no.10
Indexed
SCIE
SCOPUS
Journal Title
PHARMACEUTICALS
Volume
15
Number
10
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/146575
DOI
10.3390/ph15101215
ISSN
1424-8247
Abstract
Medicinal mushrooms are an important natural resource promoting health benefits. Herein, Phellinus linteus mycelia were prepared under submerged cultivation, the mycelium-containing culture broth was extracted as a whole to obtain the postbiotic materials (PLME), and its effect on the immune system was evaluated in normal C3H/HeN mice. Oral administration of PLME for 4 weeks was well tolerated and safe. In the PLME-administered groups, in addition to the production of immunostimulatory cytokines, such as interferon gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), and interleukin 6 (IL-6), the mitogenic activity was significantly increased. PLME administration also significantly increased the levels of serum immunoglobulin G (IgG) and IgA in the small intestinal fluid and Peyer's patches and enhanced Peyer's patch-mediated bone marrow cell proliferation activity and cytokine production (IL-2, IL-6, and IFN-gamma). Histomorphometric analyses showed an increase in immune cells in the spleen and small intestinal tissues of mice administered PLME, supporting the rationale for its immune system activation. PLME mainly contained neutral sugar (969.1 mg/g), comprising primarily of glucose as a monosaccharide unit. The beta-glucan content was 88.5 mg/g. Data suggest that PLME effectively promote immune function by stimulating the systemic immune system through the spleen and intestinal immune tissues. PLME can thus be developed as a functional ingredient to enhance immune functions.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Suh, Hyung Joo photo

Suh, Hyung Joo
보건과학대학 (바이오시스템의과학부)
Read more

Altmetrics

Total Views & Downloads

BROWSE