Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Koreaopen access
- Authors
- Chung, Y.; Kim, E.J.; Kim, H.-S.; Park, K.-H.; Baek, J.H.; Kim, J.; Lee, J.Y.; Lee, C.-S.; Lim, S.; Kim, S.-W.; Kim, E.S.; Shi, H.J.; Hong, S.H.; Jun, J.-B.; Hong, K.-W.; Choi, J.-P.; Kim, J.; Yang, K.S.; Yoon, Y.K.
- Issue Date
- 2022
- Publisher
- Korean Academy of Medical Science
- Keywords
- Coronavirus disease 2019; Neonate; Pregnancy; Severe acute respiratory syndrome coronavirus 2
- Citation
- Journal of Korean Medical Science, v.37, no.41
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Journal of Korean Medical Science
- Volume
- 37
- Number
- 41
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/147051
- DOI
- 10.3346/jkms.2022.37.e297
- ISSN
- 1011-8934
- Abstract
- Background: This study aimed to describe the maternal, obstetrical, and neonatal outcomes in pregnant women with coronavirus disease 2019 (COVID-19) and identify the predictors associated with the severity of COVID-19. Methods: This multicenter observational study included consecutive pregnant women admitted because of COVID-19 confirmed using reverse transcriptase-polymerase chain reaction (RT-PCR) test at 15 hospitals in the Republic of Korea between January 2020 and December 2021. Results: A total of 257 women with COVID-19 and 62 newborns were included in this study. Most of the patients developed this disease during the third trimester. Nine patients (7.4%) developed pregnancy-related complications. All pregnant women received inpatient treatment, of whom 9 (3.5%) required intensive care, but none of them died. The gestational age at COVID-19 diagnosis (odds ratio [OR], 1.096, 95% confidence interval [CI], 1.04–1.15) and parity (OR, 1.703, 95% CI, 1.13–2.57) were identified as significant risk factors of severe diseases. Among women who delivered, 78.5% underwent cesarean section. Preterm birth (38.5%), premature rupture of membranes (7.7%), and miscarriage (4.6%) occurred, but there was no stillbirth or neonatal death. The RT-PCR test of newborns’ amniotic fluid and umbilical cord blood samples was negative for severe acute respiratory syndrome coronavirus 2. Conclusion: At the time of COVID-19 diagnosis, gestational age and parity of pregnant women were the risk factors of disease severity. Vertical transmission of COVID-19 was not observed, and maternal severity did not significantly affect the neonatal prognosis © 2022 The Korean Academy of Medical Sciences.
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