Nelumbo nucifera promotes non-rapid eye movement sleep by regulating GABAergic receptors in rat model
DC Field | Value | Language |
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dc.contributor.author | Jo, Kyungae | - |
dc.contributor.author | Kim, Singeun | - |
dc.contributor.author | Hong, Ki-Bae | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.date.accessioned | 2021-08-30T02:15:15Z | - |
dc.date.available | 2021-08-30T02:15:15Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2021-03-01 | - |
dc.identifier.issn | 0378-8741 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/49351 | - |
dc.description.abstract | Ethnopharmacological relevance: Nelumbo nucifera are used in folk medicine for anti-depressant, anti-convulsant, neuroprotective, and many other purposes. Aim of the study: The present work evaluated the sleep potentiating effects of water extract from lotus seed in rat, and the neuropharmacological mechanisms underlying these effects. Materials and methods: Pentobarbital-induced sleep test and electroencephalogram (EEG) analysis were applied to investigate sleep latency, duration, total sleeping time and sleep quality of Lotus extract. In addition, real-time PCR and HPLC analysis were applied to analyze the signaling pathway. Results: We found that the amounts of the possible active compounds GABA (2.33 mg/g) and L-tryptophan (2.00 mg/g) were higher than quinidine (0.55 mg/g) and neferine (0.16 mg/g) in lotus seed extract. High dose (160 mg/kg) administration of lotus extract led to a tendency towards decreased sleep latency time and an increase in sleep duration time compared to the control group in a pentobarbital-induced sleep model (p < 0.05). After high dose administration, total sleep and NREM were significantly increased compared to control, while wake time and REM were significantly decreased. Lotus extract-treated rats showed significantly reduced wake time and increased sleep time in a caffeine-induced model of arousal. The transcription level of GABA(A) receptor, GABA(B) receptor, and serotonin receptor tended to increase with dose, and lotus extract showed a strong dose-dependent binding capacity to the GABA(A) receptor. Conclusion: The above results strongly suggest that GABA contained in lotus seed extract acts as a sleep potentiating compound, and that sleep-potentiating activity involves GABA(A) receptor binding. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | DEPRESSION | - |
dc.subject | EXTRACTS | - |
dc.subject | INSOMNIA | - |
dc.subject | NEFERINE | - |
dc.subject | EMBRYO | - |
dc.subject | SUSCEPTIBILITY | - |
dc.subject | METAANALYSIS | - |
dc.subject | TRYPTOPHAN | - |
dc.subject | DIVERSITY | - |
dc.subject | STRESS | - |
dc.title | Nelumbo nucifera promotes non-rapid eye movement sleep by regulating GABAergic receptors in rat model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.1016/j.jep.2020.113511 | - |
dc.identifier.scopusid | 2-s2.0-85095796533 | - |
dc.identifier.wosid | 000606372400004 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ETHNOPHARMACOLOGY, v.267 | - |
dc.relation.isPartOf | JOURNAL OF ETHNOPHARMACOLOGY | - |
dc.citation.title | JOURNAL OF ETHNOPHARMACOLOGY | - |
dc.citation.volume | 267 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | DEPRESSION | - |
dc.subject.keywordPlus | EXTRACTS | - |
dc.subject.keywordPlus | INSOMNIA | - |
dc.subject.keywordPlus | NEFERINE | - |
dc.subject.keywordPlus | EMBRYO | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | TRYPTOPHAN | - |
dc.subject.keywordPlus | DIVERSITY | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordAuthor | Nelumbo nucifera | - |
dc.subject.keywordAuthor | Sleep | - |
dc.subject.keywordAuthor | GABA(A) receptor | - |
dc.subject.keywordAuthor | GABA | - |
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