Leukotriene B-4 receptors play critical roles in house dust mites-induced neutrophilic airway inflammation and IL-17 production
DC Field | Value | Language |
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dc.contributor.author | Kwak, Dong-Wook | - |
dc.contributor.author | Park, Donghwan | - |
dc.contributor.author | Kim, Jae-Hong | - |
dc.date.accessioned | 2021-08-30T04:29:54Z | - |
dc.date.available | 2021-08-30T04:29:54Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2021-01-01 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/50179 | - |
dc.description.abstract | Increased levels of neutrophils in bronchoalveolar lavage fluid (BALF) were associated with asthma severity. As leukotriene B4 (LTB4) is a principal chemoattractant molecule for neutrophils, its receptors, BLT1 and BLT2, may contribute to neutrophil-dominant airway inflammation. In the present study, we established a mouse model of steroid-resistant, neutrophil-dominant airway inflammation by house dust mite (HDM)/lipopolysaccharide (LPS) sensitization and HDM challenge, and we investigated whether BLT1/BLT2 signaling was associated with the development of neutrophilic airway inflammation. Blockade of BLT1 or BLT2 significantly suppressed airway inflammation and IL-17 production in this mouse model. The 5-LO and 12-LO enzymes, which catalyze the synthesis of BLT1/BLT2 ligands, were also critically associated with neutrophil-dominant airway inflammation and the synthesis of IL-17. Collectively, our results suggest that the 5-/12-LO-BLT1/BLT2-linked cascade significantly contributes to neutrophil-dominant severe airway inflammation via IL-17 synthesis in HDM-induced neutrophilic asthma. (C) 2020 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | IMMUNE ACTIVATION | - |
dc.subject | ASTHMA | - |
dc.subject | CELLS | - |
dc.subject | ALLERGY | - |
dc.subject | INJURY | - |
dc.title | Leukotriene B-4 receptors play critical roles in house dust mites-induced neutrophilic airway inflammation and IL-17 production | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jae-Hong | - |
dc.identifier.doi | 10.1016/j.bbrc.2020.11.027 | - |
dc.identifier.scopusid | 2-s2.0-85096847384 | - |
dc.identifier.wosid | 000607347200022 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.534, pp.646 - 652 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 534 | - |
dc.citation.startPage | 646 | - |
dc.citation.endPage | 652 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | IMMUNE ACTIVATION | - |
dc.subject.keywordPlus | ASTHMA | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | ALLERGY | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordAuthor | HDM | - |
dc.subject.keywordAuthor | Neutrophil | - |
dc.subject.keywordAuthor | Airway inflammation | - |
dc.subject.keywordAuthor | IL-17 | - |
dc.subject.keywordAuthor | Leukotriene B4 receptors | - |
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