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Leukotriene B-4 receptors play critical roles in house dust mites-induced neutrophilic airway inflammation and IL-17 production

Authors
Kwak, Dong-WookPark, DonghwanKim, Jae-Hong
Issue Date
1-1월-2021
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
HDM; Neutrophil; Airway inflammation; IL-17; Leukotriene B4 receptors
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.534, pp.646 - 652
Indexed
SCIE
SCOPUS
Journal Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume
534
Start Page
646
End Page
652
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/50179
DOI
10.1016/j.bbrc.2020.11.027
ISSN
0006-291X
Abstract
Increased levels of neutrophils in bronchoalveolar lavage fluid (BALF) were associated with asthma severity. As leukotriene B4 (LTB4) is a principal chemoattractant molecule for neutrophils, its receptors, BLT1 and BLT2, may contribute to neutrophil-dominant airway inflammation. In the present study, we established a mouse model of steroid-resistant, neutrophil-dominant airway inflammation by house dust mite (HDM)/lipopolysaccharide (LPS) sensitization and HDM challenge, and we investigated whether BLT1/BLT2 signaling was associated with the development of neutrophilic airway inflammation. Blockade of BLT1 or BLT2 significantly suppressed airway inflammation and IL-17 production in this mouse model. The 5-LO and 12-LO enzymes, which catalyze the synthesis of BLT1/BLT2 ligands, were also critically associated with neutrophil-dominant airway inflammation and the synthesis of IL-17. Collectively, our results suggest that the 5-/12-LO-BLT1/BLT2-linked cascade significantly contributes to neutrophil-dominant severe airway inflammation via IL-17 synthesis in HDM-induced neutrophilic asthma. (C) 2020 Elsevier Inc. All rights reserved.
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생명과학대학 (생명과학부)
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