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A Case of Vanishing Bile Duct Syndrome after Drug-Induced Liver Injury Caused by Pelubiprofen

Authors
Bak, HaeinKim, HayeonLee, SieunLee, YoonseokBang, Soo-MinLee, Young-Sun
Issue Date
Dec-2020
Publisher
YONSEI UNIV COLL MEDICINE
Keywords
Pelubiprofen; vanishing bile duct syndrome; bile duct disease; drug-induced liver
Citation
YONSEI MEDICAL JOURNAL, v.61, no.12, pp.1060 - 1063
Indexed
SCIE
SCOPUS
KCI
Journal Title
YONSEI MEDICAL JOURNAL
Volume
61
Number
12
Start Page
1060
End Page
1063
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/50889
DOI
10.3349/ymj.2020.61.12.1060
ISSN
0513-5796
Abstract
Vanishing bile duct syndrome (VBDS) is a rare disease characterized by ductopenia and cholestasis, and is linked to immunological damage to the bile duct system. VBDS can be triggered by infection, ischemia, autoimmune diseases, adverse drug reactions, and humoral factors associated with malignancy. A few cases of VBDS associated with nonsteroidal anti-inflammatory drug-related drug-induced liver injury (DILI) have been reported. Here, we report a case of a 29-year-old patient who developed DILI that progressed to VBDS after the administration of pelubiprofen.
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