Unusual bridged angucyclinones and potent anticancer compounds from Streptomyces bulli GJA1
DC Field | Value | Language |
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dc.contributor.author | Kim, Jung Wha | - |
dc.contributor.author | Kwon, Yun | - |
dc.contributor.author | Bang, Sunghee | - |
dc.contributor.author | Kwon, Ha Eun | - |
dc.contributor.author | Park, Sunwoo | - |
dc.contributor.author | Lee, Yeonhee | - |
dc.contributor.author | Deyrup, Stephen T. | - |
dc.contributor.author | Song, Gwonhwa | - |
dc.contributor.author | Lee, Dongho | - |
dc.contributor.author | Joo, Hwang-Soo | - |
dc.contributor.author | Shim, Sang Hee | - |
dc.date.accessioned | 2021-08-30T09:25:53Z | - |
dc.date.available | 2021-08-30T09:25:53Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-11-07 | - |
dc.identifier.issn | 1477-0520 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/51823 | - |
dc.description.abstract | Two new unique angucyclinones (1 and 2) with unprecedented ether bridges connecting carbons 5 and 7 were isolated from the cultures of Streptomyces bulli GJA1, an endophyte of Gardenia jasminoides, together with two known ones (3 and 4). The MS2-based molecular networking system facilitated the isolation of compounds with target functionalities. The stereochemistry of 1 was completely established by ROESY and ECD experiments. Compound 3 showed antivirulence activities by inhibiting the peptide toxin (PSMs) production and the biofilm formation of MRSA. Compounds 3 and 4 showed very potent anti-proliferative effects against OV1 and ES2 ovarian cancer cells. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Unusual bridged angucyclinones and potent anticancer compounds from Streptomyces bulli GJA1 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Gwonhwa | - |
dc.contributor.affiliatedAuthor | Lee, Dongho | - |
dc.identifier.doi | 10.1039/d0ob01851a | - |
dc.identifier.scopusid | 2-s2.0-85094870899 | - |
dc.identifier.wosid | 000583823400014 | - |
dc.identifier.bibliographicCitation | ORGANIC & BIOMOLECULAR CHEMISTRY, v.18, no.41, pp.8443 - 8449 | - |
dc.relation.isPartOf | ORGANIC & BIOMOLECULAR CHEMISTRY | - |
dc.citation.title | ORGANIC & BIOMOLECULAR CHEMISTRY | - |
dc.citation.volume | 18 | - |
dc.citation.number | 41 | - |
dc.citation.startPage | 8443 | - |
dc.citation.endPage | 8449 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
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