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Unusual bridged angucyclinones and potent anticancer compounds from Streptomyces bulli GJA1
- Authors
- Kim, Jung Wha; Kwon, Yun; Bang, Sunghee; Kwon, Ha Eun; Park, Sunwoo; Lee, Yeonhee; Deyrup, Stephen T.; Song, Gwonhwa; Lee, Dongho; Joo, Hwang-Soo; Shim, Sang Hee
- Issue Date
- 7-11월-2020
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- ORGANIC & BIOMOLECULAR CHEMISTRY, v.18, no.41, pp.8443 - 8449
- Indexed
- SCIE
SCOPUS
- Journal Title
- ORGANIC & BIOMOLECULAR CHEMISTRY
- Volume
- 18
- Number
- 41
- Start Page
- 8443
- End Page
- 8449
- ISSN
- 1477-0520
- Abstract
- Two new unique angucyclinones (1 and 2) with unprecedented ether bridges connecting carbons 5 and 7 were isolated from the cultures of Streptomyces bulli GJA1, an endophyte of Gardenia jasminoides, together with two known ones (3 and 4). The MS2-based molecular networking system facilitated the isolation of compounds with target functionalities. The stereochemistry of 1 was completely established by ROESY and ECD experiments. Compound 3 showed antivirulence activities by inhibiting the peptide toxin (PSMs) production and the biofilm formation of MRSA. Compounds 3 and 4 showed very potent anti-proliferative effects against OV1 and ES2 ovarian cancer cells.
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