Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder
DC Field | Value | Language |
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dc.contributor.author | Wang, Huei Bin | - |
dc.contributor.author | Tahara, Yu | - |
dc.contributor.author | Luk, Shu Hon Christopher | - |
dc.contributor.author | Kim, Yoon-Sik | - |
dc.contributor.author | Hitchcock, Olivia N. | - |
dc.contributor.author | Kaswan, Zoe A. MacDowell | - |
dc.contributor.author | Kim, Yang In | - |
dc.contributor.author | Block, Gene D. | - |
dc.contributor.author | Ghiani, Cristina A. | - |
dc.contributor.author | Loh, Dawn H. | - |
dc.contributor.author | Colwell, Christopher S. | - |
dc.date.accessioned | 2021-08-30T09:40:27Z | - |
dc.date.available | 2021-08-30T09:40:27Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 0969-9961 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/51959 | - |
dc.description.abstract | Nighttime light pollution is linked to metabolic and cognitive dysfunction. Many patients with autism spectrum disorders (ASD) show disturbances in their sleep/wake cycle, and may be particularly vulnerable to the impact of circadian disruptors. In this study, we examined the impact of exposure to dim light at night (DLaN, 5 lx) in a model of ASD: the contactin associated protein-like 2 knock out (Cntnap2 KO) mice. DLaN was sufficient to disrupt locomotor activity rhythms, exacerbate the excessive grooming and diminish the social preference in Cntnap2 mutant mice. On a molecular level, DLaN altered the phase and amplitude of PER2:LUC rhythms in a tissue-specific manner in vitro. Daily treatment with melatonin reduced the excessive grooming of the mutant mice to wild-type levels and improved activity rhythms. Our findings suggest that common circadian disruptors such as light at night should be considered in the management of ASD. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | NEUREXIN SUPERFAMILY | - |
dc.subject | DIM LIGHT | - |
dc.subject | MEDIA USE | - |
dc.subject | SLEEP | - |
dc.subject | CHILDREN | - |
dc.subject | EXPOSURE | - |
dc.subject | NIGHT | - |
dc.subject | EPILEPSY | - |
dc.subject | IMPACT | - |
dc.subject | MEMBER | - |
dc.title | Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yang In | - |
dc.identifier.doi | 10.1016/j.nbd.2020.105064 | - |
dc.identifier.scopusid | 2-s2.0-85090731146 | - |
dc.identifier.wosid | 000579188500015 | - |
dc.identifier.bibliographicCitation | NEUROBIOLOGY OF DISEASE, v.145 | - |
dc.relation.isPartOf | NEUROBIOLOGY OF DISEASE | - |
dc.citation.title | NEUROBIOLOGY OF DISEASE | - |
dc.citation.volume | 145 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | NEUREXIN SUPERFAMILY | - |
dc.subject.keywordPlus | DIM LIGHT | - |
dc.subject.keywordPlus | MEDIA USE | - |
dc.subject.keywordPlus | SLEEP | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | EXPOSURE | - |
dc.subject.keywordPlus | NIGHT | - |
dc.subject.keywordPlus | EPILEPSY | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | MEMBER | - |
dc.subject.keywordAuthor | Autism spectrum disorder | - |
dc.subject.keywordAuthor | Circadian | - |
dc.subject.keywordAuthor | Cntnap2 | - |
dc.subject.keywordAuthor | Light pollution | - |
dc.subject.keywordAuthor | Melatonin | - |
dc.subject.keywordAuthor | Mice | - |
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