Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder
- Authors
- Wang, Huei Bin; Tahara, Yu; Luk, Shu Hon Christopher; Kim, Yoon-Sik; Hitchcock, Olivia N.; Kaswan, Zoe A. MacDowell; Kim, Yang In; Block, Gene D.; Ghiani, Cristina A.; Loh, Dawn H.; Colwell, Christopher S.
- Issue Date
- 11월-2020
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Autism spectrum disorder; Circadian; Cntnap2; Light pollution; Melatonin; Mice
- Citation
- NEUROBIOLOGY OF DISEASE, v.145
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEUROBIOLOGY OF DISEASE
- Volume
- 145
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/51959
- DOI
- 10.1016/j.nbd.2020.105064
- ISSN
- 0969-9961
- Abstract
- Nighttime light pollution is linked to metabolic and cognitive dysfunction. Many patients with autism spectrum disorders (ASD) show disturbances in their sleep/wake cycle, and may be particularly vulnerable to the impact of circadian disruptors. In this study, we examined the impact of exposure to dim light at night (DLaN, 5 lx) in a model of ASD: the contactin associated protein-like 2 knock out (Cntnap2 KO) mice. DLaN was sufficient to disrupt locomotor activity rhythms, exacerbate the excessive grooming and diminish the social preference in Cntnap2 mutant mice. On a molecular level, DLaN altered the phase and amplitude of PER2:LUC rhythms in a tissue-specific manner in vitro. Daily treatment with melatonin reduced the excessive grooming of the mutant mice to wild-type levels and improved activity rhythms. Our findings suggest that common circadian disruptors such as light at night should be considered in the management of ASD.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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