NIR-II emissive multifunctional AIEgen with single laser-activated synergistic photodynamic/photothermal therapy of cancers and pathogens
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Xu, Yuling | - |
dc.contributor.author | Zhang, Yi | - |
dc.contributor.author | Li, Jun | - |
dc.contributor.author | An, Jusung | - |
dc.contributor.author | Li, Chonglu | - |
dc.contributor.author | Bai, Suya | - |
dc.contributor.author | Sharma, Amit | - |
dc.contributor.author | Deng, Ganzhen | - |
dc.contributor.author | Kim, Jong Seung | - |
dc.contributor.author | Sun, Yao | - |
dc.date.accessioned | 2021-08-30T09:48:31Z | - |
dc.date.available | 2021-08-30T09:48:31Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/52043 | - |
dc.description.abstract | Despite the wide application of the traditional NIR-I phototheranostic platforms in basic research and clinical studies, problems such as tissue scattering, auto-fluorescence combined with aggregation caused quenching hamper precise image-guided phototherapy. Herein, we developed a multifunctional NIR-II phototheranostic platform using a novel AIE-based dye (ZSY-TPE) for single laser-activated imaging-guided combined photo thermal and photodynamic therapies of tumors and pathogens. As confirmed through in vivo studies, the ZSY-TPE dots displayed precise and efficient high-performance NIR-II imaging-guided combination phototherapy against 4T1 tumor as well as S. aureus-infected mice models without any noticeable side effects. The current study demonstrates ZSY-TPE as a powerful phototheranostic platform for precise NIR-II fluorescence/PA imaging and synergistic photodynamic/photothermal therapy of tumors and bacterial infections. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | AGGREGATION-INDUCED EMISSION | - |
dc.subject | TUMOR | - |
dc.subject | FLUOROPHORES | - |
dc.subject | NANOPARTICLES | - |
dc.subject | SYSTEMS | - |
dc.subject | DESIGN | - |
dc.subject | WINDOW | - |
dc.subject | DYE | - |
dc.title | NIR-II emissive multifunctional AIEgen with single laser-activated synergistic photodynamic/photothermal therapy of cancers and pathogens | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jong Seung | - |
dc.identifier.doi | 10.1016/j.biomaterials.2020.120315 | - |
dc.identifier.scopusid | 2-s2.0-85089667535 | - |
dc.identifier.wosid | 000571532400001 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.259 | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 259 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | AGGREGATION-INDUCED EMISSION | - |
dc.subject.keywordPlus | TUMOR | - |
dc.subject.keywordPlus | FLUOROPHORES | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | SYSTEMS | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | WINDOW | - |
dc.subject.keywordPlus | DYE | - |
dc.subject.keywordAuthor | Aggregation-induced emission | - |
dc.subject.keywordAuthor | The second infrared channel | - |
dc.subject.keywordAuthor | Organic dye | - |
dc.subject.keywordAuthor | Photothermal therapy | - |
dc.subject.keywordAuthor | Photodynamic therapy | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.