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Cited 29 time in webofscience Cited 32 time in scopus
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NIR-II emissive multifunctional AIEgen with single laser-activated synergistic photodynamic/photothermal therapy of cancers and pathogens

Authors
Xu, YulingZhang, YiLi, JunAn, JusungLi, ChongluBai, SuyaSharma, AmitDeng, GanzhenKim, Jong SeungSun, Yao
Issue Date
11월-2020
Publisher
ELSEVIER SCI LTD
Keywords
Aggregation-induced emission; The second infrared channel; Organic dye; Photothermal therapy; Photodynamic therapy
Citation
BIOMATERIALS, v.259
Indexed
SCIE
SCOPUS
Journal Title
BIOMATERIALS
Volume
259
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/52043
DOI
10.1016/j.biomaterials.2020.120315
ISSN
0142-9612
Abstract
Despite the wide application of the traditional NIR-I phototheranostic platforms in basic research and clinical studies, problems such as tissue scattering, auto-fluorescence combined with aggregation caused quenching hamper precise image-guided phototherapy. Herein, we developed a multifunctional NIR-II phototheranostic platform using a novel AIE-based dye (ZSY-TPE) for single laser-activated imaging-guided combined photo thermal and photodynamic therapies of tumors and pathogens. As confirmed through in vivo studies, the ZSY-TPE dots displayed precise and efficient high-performance NIR-II imaging-guided combination phototherapy against 4T1 tumor as well as S. aureus-infected mice models without any noticeable side effects. The current study demonstrates ZSY-TPE as a powerful phototheranostic platform for precise NIR-II fluorescence/PA imaging and synergistic photodynamic/photothermal therapy of tumors and bacterial infections.
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