Chemical Constituents from the Aerial Parts of Elsholtzia ciliata and Their Protective Activities on Glutamate-Induced HT22 Cell Death
- Authors
- Seo, Young Hye; Trinh, Tuy An; Ryu, Seung Mok; Kim, Hyo Seon; Choi, Goya; Moon, Byeong Cheol; Shim, Sang Hee; Jang, Dae Sik; Lee, Dongho; Kang, Ki Sung; Lee, Jun
- Issue Date
- 23-10월-2020
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.83, no.10, pp.3149 - 3155
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 83
- Number
- 10
- Start Page
- 3149
- End Page
- 3155
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/52417
- DOI
- 10.1021/acs.jnatprod.0c00756
- ISSN
- 0163-3864
- Abstract
- A new phenolic glucoside, (7E,9E)-3-hydroxyavenalumic acid-3-O-[6'-O-(E)-caffeoyl]-beta-D-glucopyranoside (1), and three new acetylated flavone glycosides, acacetin-7-O-[beta-D-glucopyranosyl(1 ''''-> 2 '')-4 '''-O-acetyl-alpha-L-rhamnopyranosyl(1 '''-> 6 '')]-beta-D-glucopyranoside (3), acacetin-7-O-[6 ''''-O-acetyl-beta-D-glucopyranosyl(1 ''''-> 2 '')-3 '''-O-acetyl-alpha-L-rhamnopyranosyl(1 '''-> 6 '')]-beta-D-glucopyranoside (5), and acacetin-7-O-[3 '''',6 ''''-di-O-acetyl-beta-D-glucopyranosyl(1 ''''-> 2 '')-4 ''-O-acetyl-alpha-L-rhamnopyranosyl(1 '''-> 6 '')]-beta-D-glucopyranoside (7), as well as 34 known compounds (2, 4, 6, and 8-38) were isolated from the aerial parts of Elsholtzia ciliata. The chemical structures of the new compounds were determined by spectroscopic/spectrometric data interpretation using NMR and HRESIMS. The neuroprotective effect of the isolated compounds was evaluated by a cell viability assay on HT22 murine hippocampal neuronal cells. Among them, 23 compounds, including new substances 1 and 3, exhibited neuroprotective effects against glutamate-induced HT22 cell death. In particular, compounds 2, 16, 17, 20, 22, 28, 29, and 31 presented potent neuroprotective effects with EC50 values of 1.5-8.3 mu M.
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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