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Anti-Inflammatory ent-Kaurane Diterpenoids from Isodon serra
- Authors
- Xing, Honghong; An, Lijun; Song, Ziteng; Li, Shanshan; Wang, Huimei; Wang, Chunyan; Zhang, Jie; Tuerhong, Muhetaer; Abudukeremu, Munira; Li, Dihua; Lee, Dongho; Xu, Jing; Lall, Namrita; Guo, Yuanqiang
- Issue Date
- 23-10월-2020
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.83, no.10, pp.2844 - 2853
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 83
- Number
- 10
- Start Page
- 2844
- End Page
- 2853
- ISSN
- 0163-3864
- Abstract
- Ten new ent-kaurane diterpenoids, including two pairs of epimers 1/2 and 4/5 and a 6,7-seco-ent-kauranoid 10, were obtained from the aerial parts of Isodon serra. The structures of the new compounds were confirmed by extensive spectroscopic methods and electronic circular dichroism (ECD) data analysis. An anti-inflammatory assay was applied to evaluate their nitric oxide (NO) inhibitory activities by using LPS-stimulated BV-2 cells. Compounds 1 and 9 exhibited notable NO production inhibition with IC50 values of 15.6 and 7.3 mu M, respectively. Moreover, the interactions of some bioactive diterpenoids with inducible nitric oxide synthase (iNOS) were explored by employing molecular docking studies.
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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