Large and Externally Positioned Ligand-Coated Nanopatches Facilitate the Adhesion-Dependent Regenerative Polarization of Host Macrophages
DC Field | Value | Language |
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dc.contributor.author | Min, Sunhong | - |
dc.contributor.author | Jeon, Yoo Sang | - |
dc.contributor.author | Choi, Hyojun | - |
dc.contributor.author | Khatua, Chandra | - |
dc.contributor.author | Li, Na | - |
dc.contributor.author | Bae, Gunhyu | - |
dc.contributor.author | Jung, Hee Joon | - |
dc.contributor.author | Kim, Yuri | - |
dc.contributor.author | Hong, Hyunsik | - |
dc.contributor.author | Shin, Jeongeun | - |
dc.contributor.author | Ko, Min Jun | - |
dc.contributor.author | Ko, Han Seok | - |
dc.contributor.author | Kim, Taesoon | - |
dc.contributor.author | Moon, Jun Hwan | - |
dc.contributor.author | Song, Jae-Jun | - |
dc.contributor.author | Dravid, Vinayak P. | - |
dc.contributor.author | Kim, Young Keun | - |
dc.contributor.author | Kang, Heemin | - |
dc.date.accessioned | 2021-08-30T10:53:14Z | - |
dc.date.available | 2021-08-30T10:53:14Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-10-14 | - |
dc.identifier.issn | 1530-6984 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/52458 | - |
dc.description.abstract | Macrophages can associate with extracellular matrix (ECM) demonstrating nanosequenced cell-adhesive RGD ligand. In this study, we devised barcoded materials composed of RGD-coated gold and RGD-absent iron nanopatches to show various frequencies and position of RGD-coated nanopatches with similar areas of iron and RGD-gold nanopatches that maintain macroscale and nanoscale RGD density invariant. Iron patches were used for substrate coupling. Both large (low frequency) and externally positioned RGD-coated nanopatches stimulated robust attachment in macrophages, compared with small (high frequency) and internally positioned RGD-coated nanopatches, respectively, which mediate their regenerative/anti-inflammatory M2 polarization. The nano-barcodes exhibited stability in vivo. We shed light into designing ligand-engineered nanostructures in an external position to facilitate host cell attachment, thereby eliciting regenerative host responses. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Large and Externally Positioned Ligand-Coated Nanopatches Facilitate the Adhesion-Dependent Regenerative Polarization of Host Macrophages | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Jae-Jun | - |
dc.contributor.affiliatedAuthor | Kim, Young Keun | - |
dc.contributor.affiliatedAuthor | Kang, Heemin | - |
dc.identifier.doi | 10.1021/acs.nanolett.0c02655 | - |
dc.identifier.scopusid | 2-s2.0-85092945335 | - |
dc.identifier.wosid | 000598727300045 | - |
dc.identifier.bibliographicCitation | NANO LETTERS, v.20, no.10, pp.7272 - 7280 | - |
dc.relation.isPartOf | NANO LETTERS | - |
dc.citation.title | NANO LETTERS | - |
dc.citation.volume | 20 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 7272 | - |
dc.citation.endPage | 7280 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.subject.keywordAuthor | RGD nanopatches | - |
dc.subject.keywordAuthor | RGD frequency | - |
dc.subject.keywordAuthor | macrophage adhesion | - |
dc.subject.keywordAuthor | macrophage polarization | - |
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