Large and Externally Positioned Ligand-Coated Nanopatches Facilitate the Adhesion-Dependent Regenerative Polarization of Host Macrophages
- Authors
- Min, Sunhong; Jeon, Yoo Sang; Choi, Hyojun; Khatua, Chandra; Li, Na; Bae, Gunhyu; Jung, Hee Joon; Kim, Yuri; Hong, Hyunsik; Shin, Jeongeun; Ko, Min Jun; Ko, Han Seok; Kim, Taesoon; Moon, Jun Hwan; Song, Jae-Jun; Dravid, Vinayak P.; Kim, Young Keun; Kang, Heemin
- Issue Date
- 14-10월-2020
- Publisher
- AMER CHEMICAL SOC
- Keywords
- RGD nanopatches; RGD frequency; macrophage adhesion; macrophage polarization
- Citation
- NANO LETTERS, v.20, no.10, pp.7272 - 7280
- Indexed
- SCIE
SCOPUS
- Journal Title
- NANO LETTERS
- Volume
- 20
- Number
- 10
- Start Page
- 7272
- End Page
- 7280
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/52458
- DOI
- 10.1021/acs.nanolett.0c02655
- ISSN
- 1530-6984
- Abstract
- Macrophages can associate with extracellular matrix (ECM) demonstrating nanosequenced cell-adhesive RGD ligand. In this study, we devised barcoded materials composed of RGD-coated gold and RGD-absent iron nanopatches to show various frequencies and position of RGD-coated nanopatches with similar areas of iron and RGD-gold nanopatches that maintain macroscale and nanoscale RGD density invariant. Iron patches were used for substrate coupling. Both large (low frequency) and externally positioned RGD-coated nanopatches stimulated robust attachment in macrophages, compared with small (high frequency) and internally positioned RGD-coated nanopatches, respectively, which mediate their regenerative/anti-inflammatory M2 polarization. The nano-barcodes exhibited stability in vivo. We shed light into designing ligand-engineered nanostructures in an external position to facilitate host cell attachment, thereby eliciting regenerative host responses.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- College of Engineering > Department of Materials Science and Engineering > 1. Journal Articles
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