Shape Analysis of the Subcortical Nuclei in Amyotrophic Lateral Sclerosis without Cognitive Impairment
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tae, Woo-Suk | - |
dc.contributor.author | Sung, Joo Hye | - |
dc.contributor.author | Baek, Seol-Hee | - |
dc.contributor.author | Lee, Chan-Nyoung | - |
dc.contributor.author | Kim, Byung-Jo | - |
dc.date.accessioned | 2021-08-30T12:51:41Z | - |
dc.date.available | 2021-08-30T12:51:41Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 1738-6586 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/52574 | - |
dc.description.abstract | Background and Purpose Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that mainly affects the pyramidal motor system. However, recent studies have suggested that degeneration of the extramotor system plays a role in the disability experienced by patients with ALS. We investigated the local shape changes and mean volumes of the subcortical nuclei in sporadic ALS patients with preserved cognition. Methods The participants comprised 32 patients with ALS and 43 age- and sex-matched healthy controls. Three-dimensional T1-weighted structural images were acquired. Surface-based vertex analysis was performed with fully automated segmentation of both amygdalae, hippocampi, caudate nuclei, nuclei accumbens, putamina, pallida, and thalami, and the brain-stem. The scalar distances from the mean surfaces of the individual subcortical nuclei were compared between groups, and correlations of the local shape distances with initial Amyotrophic Lateral Sclerosis Functional Rating Scale Revised (ALS-FRS-R) scores and the delta FRS-R and with the disease duration were analyzed. Results ALS patients showed regional shape contractions on the lateral surfaces of both pallida, the lateroposterior surface of the right putamen, and the anterior basal surface of the right accumbens. Delta FRS-R scores were negatively correlated with local shape distances in the right hippocampus and the putamina. However, the initial ALS-FRS-R score and disease duration were not correlated with local shape distances. Conclusions Subcortical gray-matter structures are involved in the neurodegenerative process of ALS before cognitive impairment becomes evident. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN NEUROLOGICAL ASSOC | - |
dc.subject | BASAL GANGLIA | - |
dc.subject | DOPAMINERGIC DEFICIT | - |
dc.subject | ALS | - |
dc.subject | PARKINSONISM | - |
dc.subject | INVOLVEMENT | - |
dc.subject | PATHOLOGY | - |
dc.subject | DISORDER | - |
dc.subject | CRITERIA | - |
dc.title | Shape Analysis of the Subcortical Nuclei in Amyotrophic Lateral Sclerosis without Cognitive Impairment | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Tae, Woo-Suk | - |
dc.contributor.affiliatedAuthor | Kim, Byung-Jo | - |
dc.identifier.doi | 10.3988/jcn.2020.16.4.592 | - |
dc.identifier.scopusid | 2-s2.0-85092899974 | - |
dc.identifier.wosid | 000582755300009 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL NEUROLOGY, v.16, no.4, pp.592 - 598 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL NEUROLOGY | - |
dc.citation.title | JOURNAL OF CLINICAL NEUROLOGY | - |
dc.citation.volume | 16 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 592 | - |
dc.citation.endPage | 598 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002632216 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.subject.keywordPlus | BASAL GANGLIA | - |
dc.subject.keywordPlus | DOPAMINERGIC DEFICIT | - |
dc.subject.keywordPlus | ALS | - |
dc.subject.keywordPlus | PARKINSONISM | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.subject.keywordPlus | PATHOLOGY | - |
dc.subject.keywordPlus | DISORDER | - |
dc.subject.keywordPlus | CRITERIA | - |
dc.subject.keywordAuthor | amyotrophic lateral sclerosis | - |
dc.subject.keywordAuthor | magnetic resonance imaging | - |
dc.subject.keywordAuthor | extrapyramidal tracts | - |
dc.subject.keywordAuthor | basal ganglia | - |
dc.subject.keywordAuthor | thalamus | - |
dc.subject.keywordAuthor | hippocampus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.