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Shape Analysis of the Subcortical Nuclei in Amyotrophic Lateral Sclerosis without Cognitive Impairment

Authors
Tae, Woo-SukSung, Joo HyeBaek, Seol-HeeLee, Chan-NyoungKim, Byung-Jo
Issue Date
10월-2020
Publisher
KOREAN NEUROLOGICAL ASSOC
Keywords
amyotrophic lateral sclerosis; magnetic resonance imaging; extrapyramidal tracts; basal ganglia; thalamus; hippocampus
Citation
JOURNAL OF CLINICAL NEUROLOGY, v.16, no.4, pp.592 - 598
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF CLINICAL NEUROLOGY
Volume
16
Number
4
Start Page
592
End Page
598
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/52574
DOI
10.3988/jcn.2020.16.4.592
ISSN
1738-6586
Abstract
Background and Purpose Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that mainly affects the pyramidal motor system. However, recent studies have suggested that degeneration of the extramotor system plays a role in the disability experienced by patients with ALS. We investigated the local shape changes and mean volumes of the subcortical nuclei in sporadic ALS patients with preserved cognition. Methods The participants comprised 32 patients with ALS and 43 age- and sex-matched healthy controls. Three-dimensional T1-weighted structural images were acquired. Surface-based vertex analysis was performed with fully automated segmentation of both amygdalae, hippocampi, caudate nuclei, nuclei accumbens, putamina, pallida, and thalami, and the brain-stem. The scalar distances from the mean surfaces of the individual subcortical nuclei were compared between groups, and correlations of the local shape distances with initial Amyotrophic Lateral Sclerosis Functional Rating Scale Revised (ALS-FRS-R) scores and the delta FRS-R and with the disease duration were analyzed. Results ALS patients showed regional shape contractions on the lateral surfaces of both pallida, the lateroposterior surface of the right putamen, and the anterior basal surface of the right accumbens. Delta FRS-R scores were negatively correlated with local shape distances in the right hippocampus and the putamina. However, the initial ALS-FRS-R score and disease duration were not correlated with local shape distances. Conclusions Subcortical gray-matter structures are involved in the neurodegenerative process of ALS before cognitive impairment becomes evident.
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