Detailed Information

Cited 2 time in webofscience Cited 2 time in scopus
Metadata Downloads

Reduced plasma Fetuin-A is a promising biomarker of depression in the elderly

Authors
Fanelli, GiuseppeBenedetti, FrancescoWang, Sheng-MinLee, Soo-JungJun, Tae-YounMasand, Prakash S.Patkar, Ashwin A.Han, ChangsuSerretti, AlessandroPae, Chi-UnFabbri, Chiara
Issue Date
10월-2020
Publisher
SPRINGER HEIDELBERG
Keywords
Major depression; Biomarkers; Neuroinflammation; Elderly; Fetuin-A; Prolactin
Citation
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, v.270, no.7, pp.901 - 910
Indexed
SCIE
SCOPUS
Journal Title
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
Volume
270
Number
7
Start Page
901
End Page
910
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/52654
DOI
10.1007/s00406-019-01090-1
ISSN
0940-1334
Abstract
Depression affects 7% of the elderly population, and it often remains misdiagnosed or untreated. Peripheral biomarkers might aid clinicians by allowing more accurate and well-timed recognition of the disease. We sought to determine if plasma protein levels predict the severity of depressive symptomatology or distinguish patients from healthy individuals. The severity of depressive symptoms and global cognitive functioning were assessed by the Geriatric Depression Scale (GDS) and Mini-Mental State Examination (MMSE) in 152 elderly subjects, 76 of which with major depressive disorder (MDD). Plasma levels of 24 proteins were measured by multiplexing and analyzed as continuous predictors or dichotomized using the median value. The association between individual plasma proteins and MDD risk or depressive symptoms severity was investigated using multiple logistic and linear regressions including relevant covariates. Sensitivity analyses were performed excluding cognitively impaired individuals or non-acute patients with MDD. After adjusting for possible confounders and false discovery rate (FDR) correction, we found lower Fetuin-A levels in MDD patients vs. controls (p(FDR) = 1.95 x 10(-6)). This result was confirmed by the sensitivity and dichotomized analyses. Lower prolactin (PRL) levels predicted more severe depressive symptoms in acute MDD patients (p(FDR) = 0.024). Fetuin-A is a promising biomarker of MDD in the elderly as this protein was negatively associated with the disorder in our sample, regardless of the global cognitive functioning. Lower PRL levels may be a peripheral signature of impaired neuroprotective processes and serotoninergic neurotransmission in more severely depressed patients.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Han, Chang su photo

Han, Chang su
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE