Gold-Nanoparticle Layer Substrate Assisted Transmission-Mode Laser Desorption for Atmospheric Pressure Mass Spectrometry Imaging
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jae Young | - |
dc.contributor.author | Lim, Heejin | - |
dc.contributor.author | Lee, Sun Young | - |
dc.contributor.author | Lee, Gwanjin | - |
dc.contributor.author | Lim, Dong-Kwon | - |
dc.contributor.author | Moon, Dae Won | - |
dc.contributor.author | Song, Cheol | - |
dc.date.accessioned | 2021-08-30T13:04:22Z | - |
dc.date.available | 2021-08-30T13:04:22Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 1947-2935 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/52687 | - |
dc.description.abstract | We demonstrate continuous-wave laser-based ambient mass spectrometry imaging with the use of a gold-nanoparticle layer substrate. When a fresh tissue slice is placed on a gold-nanoparticle layer substrate and irradiated with a 532-nm continuous-wave laser, the transmission-mode laser configuration provides precise desorption performance to facilitate mass spectrometry imaging. The subsequent ionization process with non-thermal atmospheric pressure plasma jets generates sufficient amounts of molecular ions. By using this method, micrometer-spatial-resolution mass spectrometry imaging of humid tissues can be obtained. The gold-nanoparticle layer substrates can be prepared and stored in advance of the experiment, resulting in simplified specimen preparation and an advantage in faster preparing of fresh tissue specimen for analysis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER SCIENTIFIC PUBLISHERS | - |
dc.subject | ELECTROSPRAY-IONIZATION | - |
dc.subject | ION-SOURCE | - |
dc.subject | IN-VIVO | - |
dc.subject | DESORPTION/IONIZATION | - |
dc.title | Gold-Nanoparticle Layer Substrate Assisted Transmission-Mode Laser Desorption for Atmospheric Pressure Mass Spectrometry Imaging | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lim, Dong-Kwon | - |
dc.identifier.doi | 10.1166/sam.2020.3792 | - |
dc.identifier.wosid | 000585183900012 | - |
dc.identifier.bibliographicCitation | SCIENCE OF ADVANCED MATERIALS, v.12, no.10, pp.1517 - 1523 | - |
dc.relation.isPartOf | SCIENCE OF ADVANCED MATERIALS | - |
dc.citation.title | SCIENCE OF ADVANCED MATERIALS | - |
dc.citation.volume | 12 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1517 | - |
dc.citation.endPage | 1523 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.subject.keywordPlus | ELECTROSPRAY-IONIZATION | - |
dc.subject.keywordPlus | ION-SOURCE | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | DESORPTION/IONIZATION | - |
dc.subject.keywordAuthor | Mass Spectrometry Imaging | - |
dc.subject.keywordAuthor | Gold-Nanoparticle Layer Substrate | - |
dc.subject.keywordAuthor | Laser Desorption | - |
dc.subject.keywordAuthor | Ambient Mass Spectrometry | - |
dc.subject.keywordAuthor | Tissue Imaging | - |
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