Gold-Nanoparticle Layer Substrate Assisted Transmission-Mode Laser Desorption for Atmospheric Pressure Mass Spectrometry Imaging
- Authors
- Kim, Jae Young; Lim, Heejin; Lee, Sun Young; Lee, Gwanjin; Lim, Dong-Kwon; Moon, Dae Won; Song, Cheol
- Issue Date
- 10월-2020
- Publisher
- AMER SCIENTIFIC PUBLISHERS
- Keywords
- Mass Spectrometry Imaging; Gold-Nanoparticle Layer Substrate; Laser Desorption; Ambient Mass Spectrometry; Tissue Imaging
- Citation
- SCIENCE OF ADVANCED MATERIALS, v.12, no.10, pp.1517 - 1523
- Indexed
- SCIE
- Journal Title
- SCIENCE OF ADVANCED MATERIALS
- Volume
- 12
- Number
- 10
- Start Page
- 1517
- End Page
- 1523
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/52687
- DOI
- 10.1166/sam.2020.3792
- ISSN
- 1947-2935
- Abstract
- We demonstrate continuous-wave laser-based ambient mass spectrometry imaging with the use of a gold-nanoparticle layer substrate. When a fresh tissue slice is placed on a gold-nanoparticle layer substrate and irradiated with a 532-nm continuous-wave laser, the transmission-mode laser configuration provides precise desorption performance to facilitate mass spectrometry imaging. The subsequent ionization process with non-thermal atmospheric pressure plasma jets generates sufficient amounts of molecular ions. By using this method, micrometer-spatial-resolution mass spectrometry imaging of humid tissues can be obtained. The gold-nanoparticle layer substrates can be prepared and stored in advance of the experiment, resulting in simplified specimen preparation and an advantage in faster preparing of fresh tissue specimen for analysis.
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Collections - Graduate School > KU-KIST Graduate School of Converging Science and Technology > 1. Journal Articles
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