Constituents from Solidago virgaurea var. gigantea and their inhibitory effect on lipid accumulation
- Authors
- Jang, Young Soo; Kim, Hyun-Yong; Zuo, Guanglei; Lee, Eun Hee; Kang, Sung Kwon; Lim, Soon Sung
- Issue Date
- 10월-2020
- Publisher
- ELSEVIER
- Keywords
- Solidago viraurea var. gigantean (Nakai); Anti-adipogenic activity; Lipid accumulation; (1R,2S,3S,5R,7S)-methyl 7-((cinnamoyloxy) methyl)-2,3-dihydroxy-6,8-dioxabicyclo[3.2.1]; octane-5-carboxylate
- Citation
- FITOTERAPIA, v.146
- Indexed
- SCIE
SCOPUS
- Journal Title
- FITOTERAPIA
- Volume
- 146
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/53016
- DOI
- 10.1016/j.fitote.2020.104683
- ISSN
- 0367-326X
- Abstract
- In this study, the anti-adipogenic activities of compounds isolated from Solidago viraurea var. gigantea (SG) extracts were investigated using Oil Red O staining in the 3T3-L1 cell line. Four known compounds including 3,5-di-O-caffeoylquinic acid (5), protocatechuic acid (6), chlorogenic acid (7), and kaempferol-3-O-rutinoside (8), and four undescribed compounds including (1R,2S,3S,5R,7S)-methyl 7-((cinnamoyloxy)methyl)-2,3-dihydroxy-6,8-dioxabicyclo[3.2.1]-octane-5-carboxylate (1), (1R,2S,3S,5R,7S)-methyl 2,3-dihydroxy-7-((((Z)-3-phenylacryloyl)oxy)methyl)-6,8-dioxabicyclo[3.2.1]-octane-5-carboxylate (2), (1R,2S,3S,5R,7S)-2,3-dihydroxy-7((((Z)-3-phenylacryloyl)oxy)methyl)-6,8-dioxabicyclo[3.2.1]-octane-5-carboxylic acid (3), and (1R,2S,3S,5R,7S)7-((cinnamoyloxy)methyl)-2,3-dihydroxy-6,8-dioxabicyclo-[3.2.1]-octane-5-carboxylic acid (4) were isolated from S. viraurea var. gigantea. The structures of the compounds were first identified by comparing their H-1 NMR spectra with spectral data from the literature and a more detailed identification was then performed using 2D NMR (Correlated spectroscopy (COSY), heteronuclear single quantum correlation (HSQC), heteronuclear multiple bond correlation (HMBC), and nuclear overhauser spectroscopy (NOESY)), and X-ray crystallography analyses. The anti-adipogenic activities of all compounds were evaluated by MTT assay and Oil Red O staining in 3T3-L1 cells. 3,5-di-O-caffeoylquinic acid was found to inhibit lipid accumulation more potently than the other tested compounds.
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