Regional analysis of cerebral hemodynamic changes during the head-up tilt test in Parkinson's disease patients with orthostatic intolerance
- Authors
- Phillips, Zephaniah, V; Kim, Jung Bin; Paik, Seung-Ho; Kang, Shin-Young; Jeon, Nam-Joon; Kim, Beop-Min; Kim, Byung-Jo
- Issue Date
- 10월-2020
- Publisher
- SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
- Keywords
- autonomic dysfunction; automated anatomical labeling; diffuse optical tomography; head-up tilt; orthostatic hypotension; Parkinson' s disease
- Citation
- NEUROPHOTONICS, v.7, no.4
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEUROPHOTONICS
- Volume
- 7
- Number
- 4
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/53043
- DOI
- 10.1117/1.NPh.7.4.045006
- ISSN
- 2329-4248
- Abstract
- Significance: Cerebral oxygenation changes in the superior, middle, and medial gyri were used to elucidate spatial impairments of autonomic hemodynamic recovery during the head-up tilt table test (HUTT) in Parkinson's disease (PD) patients with orthostatic intolerance (OI) symptoms. Aim: To analyze dynamic oxygenation changes during the HUTT and classify PD patients with OI symptoms using clinical and oxygenation features. Approach: Thirty-nine PD patients with OI symptoms [10: orthostatic hypotension (PD-OH); 29: normal HUTT results (PD-NOR)] and seven healthy controls (HCs) were recruited. Prefrontal oxyhemoglobin (HbO) changes during the HUTT were reconstructed with diffuse optical tomography and segmented using the automated anatomical labeling system. Decision trees were used for classification. Results: HCs and PD-NOR patients with positive rates of HbO change (PD-POS) showed the greatest HbO recovery in the superior frontal gyrus (SFG) during tilt. PD-OH and PD-NOR patients with negative rates of HbO change (PD-NEG) showed asymmetric reoxygenation. The classification accuracy was 89.4% for PD-POS versus PD-NEG, 71% for PD-NOR versus PD-OH, and 55.8% for PD-POS versus PD-NEG versus PD-OH. The oxygenation features were more discriminative than the clinical features. Conclusions: PD-OH showed decreased right SFG function, which may be associated with impaired compensatory autonomic responses to orthostatic stress. (C) The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License.
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- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Bioengineering > 1. Journal Articles
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